Abstract
The expression of cytokeratins in gastrointestinal stromal tumours (GISTs) is rare and may lead to diagnostic confusion when it occurs. This report describes a metastatic GIST that stained strongly for cytokeratins, CD117, and CD34 in a patient who was previously diagnosed with gastric epithelioid angiosarcoma. A review of both tumours showed the same histological and immunohistochemical profiles, and c-kit molecular analysis revealed an insertional mutation at codon 558 of exon 11 in both tumours. Thus, pathologists should be aware that GISTs can occasionally express cytokeratins, and that c-kit mutational investigations may have a key diagnostic role and may prevent diagnostic mistakes that could have important clinical implications.
| Original language | English |
|---|---|
| Pages (from-to) | 991-993 |
| Number of pages | 3 |
| Journal | Journal of Clinical Pathology |
| Volume | 58 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2005 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
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The value of c-kit mutational analysis in a cytokeratin positive gastrointestinal stromal tumour. / Rossi, G.; Sartori, G.; Valli, R.; Bertolini, F.; Bigiani, N.; Schirosi, L.; Cavazza, A.; Luppi, G.
In: Journal of Clinical Pathology, Vol. 58, No. 9, 09.2005, p. 991-993.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The value of c-kit mutational analysis in a cytokeratin positive gastrointestinal stromal tumour
AU - Rossi, G.
AU - Sartori, G.
AU - Valli, R.
AU - Bertolini, F.
AU - Bigiani, N.
AU - Schirosi, L.
AU - Cavazza, A.
AU - Luppi, G.
PY - 2005/9
Y1 - 2005/9
N2 - The expression of cytokeratins in gastrointestinal stromal tumours (GISTs) is rare and may lead to diagnostic confusion when it occurs. This report describes a metastatic GIST that stained strongly for cytokeratins, CD117, and CD34 in a patient who was previously diagnosed with gastric epithelioid angiosarcoma. A review of both tumours showed the same histological and immunohistochemical profiles, and c-kit molecular analysis revealed an insertional mutation at codon 558 of exon 11 in both tumours. Thus, pathologists should be aware that GISTs can occasionally express cytokeratins, and that c-kit mutational investigations may have a key diagnostic role and may prevent diagnostic mistakes that could have important clinical implications.
AB - The expression of cytokeratins in gastrointestinal stromal tumours (GISTs) is rare and may lead to diagnostic confusion when it occurs. This report describes a metastatic GIST that stained strongly for cytokeratins, CD117, and CD34 in a patient who was previously diagnosed with gastric epithelioid angiosarcoma. A review of both tumours showed the same histological and immunohistochemical profiles, and c-kit molecular analysis revealed an insertional mutation at codon 558 of exon 11 in both tumours. Thus, pathologists should be aware that GISTs can occasionally express cytokeratins, and that c-kit mutational investigations may have a key diagnostic role and may prevent diagnostic mistakes that could have important clinical implications.
UR - http://www.scopus.com/inward/record.url?scp=24644468207&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24644468207&partnerID=8YFLogxK
U2 - 10.1136/jcp.2004.024364
DO - 10.1136/jcp.2004.024364
M3 - Article
C2 - 16126886
AN - SCOPUS:24644468207
VL - 58
SP - 991
EP - 993
JO - Journal of Clinical Pathology - Clinical Molecular Pathology
JF - Journal of Clinical Pathology - Clinical Molecular Pathology
SN - 0021-9746
IS - 9
ER -