The value of c-kit mutational analysis in a cytokeratin positive gastrointestinal stromal tumour

G. Rossi, G. Sartori, R. Valli, F. Bertolini, N. Bigiani, L. Schirosi, A. Cavazza, G. Luppi

Research output: Contribution to journalArticlepeer-review

Abstract

The expression of cytokeratins in gastrointestinal stromal tumours (GISTs) is rare and may lead to diagnostic confusion when it occurs. This report describes a metastatic GIST that stained strongly for cytokeratins, CD117, and CD34 in a patient who was previously diagnosed with gastric epithelioid angiosarcoma. A review of both tumours showed the same histological and immunohistochemical profiles, and c-kit molecular analysis revealed an insertional mutation at codon 558 of exon 11 in both tumours. Thus, pathologists should be aware that GISTs can occasionally express cytokeratins, and that c-kit mutational investigations may have a key diagnostic role and may prevent diagnostic mistakes that could have important clinical implications.

Original languageEnglish
Pages (from-to)991-993
Number of pages3
JournalJournal of Clinical Pathology
Volume58
Issue number9
DOIs
Publication statusPublished - Sep 2005

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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