Lesioni encefaliche con contrast-enhancement in pazienti affetti da sclerosi multipla: Confronto tra sequenze spin-echo T1-pesate convenzionali e con saturazione spettrale del grasso

Translated title of the contribution: The value of chemical fat-saturation pulse added to T1-weighted spin-echo sequence in evaluating gadolinium-enhancing brain lesions in multiple sclerosis

F. Sardanelli, S. Schiavoni, A. Iozzelli, A. Fausto, A. Aliprandi, G. L. Mancardi, M. Filippi

Research output: Contribution to journalArticle

Abstract

Purpose. This study was undertaken to assess the value of a chemical (spectral) fat-saturation (fat-sat) pulse added to a T1-weighted spin-echo sequence after intravenous administration of paramagnetic contrast agent in detecting enhancing lesions in multiple sclerosis. Materials and methods. Twenty patients with relapsing-remitting multiple sclerosis underwent a brain 1.0-Tesla magnetic resonance (MR) scan with T1-weighted spin-echo sequences (24 contiguous para-axial slices with a thickness of 5 mm, pixel size 0.96 mm 2, number of excitations 2, flip angle 90°) 5 min after intravenous injection of 0.1 mmol/kg of gadodiamide with and without fat-sat, acquired with randomised order of priority. Two readers counted by consensus the number of enhancing lesions and assigned a conspicuity score (low conspicuity=1; high conspicuity=2) to each enhancing lesion during a randomised reading without any visual comparison between the two corresponding images (with and without fat-sat) of the same patient. McNemar and Wilcoxon matched-pair signed-rank tests were used. Results. Seventy-two enhancing lesions without fat-sat and 94 with fat-sat were detected; 22 lesions were visible only with fatsat, whereas no lesion was detected only without fat-sat (p

Translated title of the contributionThe value of chemical fat-saturation pulse added to T1-weighted spin-echo sequence in evaluating gadolinium-enhancing brain lesions in multiple sclerosis
Original languageItalian
Pages (from-to)1244-1251
Number of pages8
JournalRadiologia Medica
Volume112
Issue number8
DOIs
Publication statusPublished - Dec 2007

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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