The Value of Flow Cytometric Analysis in Patients With Gastric Cancer

Houston Johnson, Claudio Belluco, Shahla Masood, Abdul Moneim Abou Azama, Leonard Kahn, Leslie Wise

Research output: Contribution to journalArticlepeer-review

Abstract

Tumors in the gastric cardia and the body/antrum were studied to determine the effect of ploidy and S-phase fractions on patient survival. Forty-two percent of tumors were located in the cardia and 58% in the body/antrum. Nodal metastases occurred more often with cardia tumors than with body/antrum tumors (86% vs 65%). Aneuploidy occurred more frequently in patients with cardia tumors than in patients with body/antrum tumors (39% vs 20%). Metastasis to lymph nodes was more common in patients with aneuploidy than in patients with diploidy (31 % vs 7%). S-phase fractions were not different between aneuploid and diploid tumors. More patients with diploid cancer were alive at 5 years than were patients with aneuploid tumors (90% vs 10%). We conclude that primary cellular differences in gastric tumors of the cardia or body/antrum determine patient survival. (Arch Surg. 1993;128:314-317).

Original languageEnglish
Pages (from-to)314-317
Number of pages4
JournalArchives of Surgery
Volume128
Issue number3
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Surgery

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