The Value of Flow Cytometric Analysis in Patients With Gastric Cancer

Houston Johnson; Claudio Belluco; Shahla Masood; Abdul Moneim Abou Azama; Leonard Kahn; Leslie Wise

doi:10.1001/archsurg.1993.01420150070013

The Value of Flow Cytometric Analysis in Patients With Gastric Cancer

Houston Johnson, Claudio Belluco, Shahla Masood, Abdul Moneim Abou Azama, Leonard Kahn, Leslie Wise

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

Tumors in the gastric cardia and the body/antrum were studied to determine the effect of ploidy and S-phase fractions on patient survival. Forty-two percent of tumors were located in the cardia and 58% in the body/antrum. Nodal metastases occurred more often with cardia tumors than with body/antrum tumors (86% vs 65%). Aneuploidy occurred more frequently in patients with cardia tumors than in patients with body/antrum tumors (39% vs 20%). Metastasis to lymph nodes was more common in patients with aneuploidy than in patients with diploidy (31 % vs 7%). S-phase fractions were not different between aneuploid and diploid tumors. More patients with diploid cancer were alive at 5 years than were patients with aneuploid tumors (90% vs 10%). We conclude that primary cellular differences in gastric tumors of the cardia or body/antrum determine patient survival. (Arch Surg. 1993;128:314-317).

Original language	English
Pages (from-to)	314-317
Number of pages	4
Journal	Archives of Surgery
Volume	128
Issue number	3
DOIs	https://doi.org/10.1001/archsurg.1993.01420150070013
Publication status	Published - 1993

ASJC Scopus subject areas

Surgery

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title = "The Value of Flow Cytometric Analysis in Patients With Gastric Cancer",

abstract = "Tumors in the gastric cardia and the body/antrum were studied to determine the effect of ploidy and S-phase fractions on patient survival. Forty-two percent of tumors were located in the cardia and 58% in the body/antrum. Nodal metastases occurred more often with cardia tumors than with body/antrum tumors (86% vs 65%). Aneuploidy occurred more frequently in patients with cardia tumors than in patients with body/antrum tumors (39% vs 20%). Metastasis to lymph nodes was more common in patients with aneuploidy than in patients with diploidy (31 % vs 7%). S-phase fractions were not different between aneuploid and diploid tumors. More patients with diploid cancer were alive at 5 years than were patients with aneuploid tumors (90% vs 10%). We conclude that primary cellular differences in gastric tumors of the cardia or body/antrum determine patient survival. (Arch Surg. 1993;128:314-317).",

author = "Houston Johnson and Claudio Belluco and Shahla Masood and {Abou Azama}, {Abdul Moneim} and Leonard Kahn and Leslie Wise",

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AU - Johnson, Houston

AU - Belluco, Claudio

AU - Masood, Shahla

AU - Abou Azama, Abdul Moneim

AU - Kahn, Leonard

AU - Wise, Leslie

PY - 1993

Y1 - 1993

N2 - Tumors in the gastric cardia and the body/antrum were studied to determine the effect of ploidy and S-phase fractions on patient survival. Forty-two percent of tumors were located in the cardia and 58% in the body/antrum. Nodal metastases occurred more often with cardia tumors than with body/antrum tumors (86% vs 65%). Aneuploidy occurred more frequently in patients with cardia tumors than in patients with body/antrum tumors (39% vs 20%). Metastasis to lymph nodes was more common in patients with aneuploidy than in patients with diploidy (31 % vs 7%). S-phase fractions were not different between aneuploid and diploid tumors. More patients with diploid cancer were alive at 5 years than were patients with aneuploid tumors (90% vs 10%). We conclude that primary cellular differences in gastric tumors of the cardia or body/antrum determine patient survival. (Arch Surg. 1993;128:314-317).

AB - Tumors in the gastric cardia and the body/antrum were studied to determine the effect of ploidy and S-phase fractions on patient survival. Forty-two percent of tumors were located in the cardia and 58% in the body/antrum. Nodal metastases occurred more often with cardia tumors than with body/antrum tumors (86% vs 65%). Aneuploidy occurred more frequently in patients with cardia tumors than in patients with body/antrum tumors (39% vs 20%). Metastasis to lymph nodes was more common in patients with aneuploidy than in patients with diploidy (31 % vs 7%). S-phase fractions were not different between aneuploid and diploid tumors. More patients with diploid cancer were alive at 5 years than were patients with aneuploid tumors (90% vs 10%). We conclude that primary cellular differences in gastric tumors of the cardia or body/antrum determine patient survival. (Arch Surg. 1993;128:314-317).

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The Value of Flow Cytometric Analysis in Patients With Gastric Cancer

Abstract

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