The Veneto Region's Barrett's Oesophagus Registry

Aims, methods, preliminary results

G. Zaninotto, F. Minnei, E. Guirroli, M. Ceolin, G. Battaglia, A. Bellumat, G. Betetto, L. Bozzola, M. Cassaro, G. Cataudella, N. Dal Bò, F. Farinati, G. Florea, A. Furlanetto, E. Galliani, B. Germanà, A. Guerini, E. Macrì, V. Marcon, G. Mastropaolo & 8 others A. Meggio, G. Miori, L. Morelli, B. Murer, L. Norberto, R. Togni, F. Valiante, M. Rugge

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: The natural history of Barrett's Oeosphagus is not completely clarified and Barrett's Oeosphagus Registries are considered useful tools to expand our knowledge on this disease. A Barrett's Oeosphagus Registry has been therefore established in the Veneto Region and neighbouring provinces. Aims: The aims of the Registry are to assess the demographical, endoscopical and histological characteristics of Barrett's Oeosphagus patients; the prevalence of non-invasive neoplasia and Barrett's Adenocarcinoma and the timing and incidence of Barrett's Oeosphagus progression to malignancy. Methods: An interdisciplinary committee of endoscopists, pathologists and information technology experts was established in 2004 to design a website-based Barrett's Oesophagus Registry for the Veneto Region and neighbouring north-eastern Italian provinces. Protocols for endoscopies and biopsies and standard reports were carefully defined. Results: In the first 18 months, 397 patients with endoscopically visible and histologically proven Barrett's Oeosphagus were enrolled in the Registry; the median age of these patients was 66 years (male:female = 3:1). Most patients (75%) had a Short Segment of Barrett's Oesophagus (≤3 cm) and only 1 in 4 had a Long Segment of Barrett's Oesophagus (>3 cm). Long Segment of Barrett's Oesophagus patients were 5 years older than the Short Segment of Barrett's Oesophagus patients (p <0.05), suggesting a progression from Short Segment of Barrett's Oesophagus to Long Segment of Barrett's Oesophagus. Though no data are available on the incidence of non-invasive neoplasia or Barrett's Adenocarcinoma (i.e., progression to cancer at least 12 months after enrolment), the prevalence of neoplastic lesions (found within 12 months of enrolment) was 5% for Short Segment of Barrett's Oesophagus and 19% for Long Segment of Barrett's Oesophagus, indicating that a careful multiple-biopsy endoscopic protocol is needed, especially when Long Segment of Barrett's Oesophagus are suspected at endoscopy. The prevalence of Barrett's Adenocarcinoma among patients with non-invasive neoplasia was 1/17 cases of low-grade non-invasive neoplasia and 2/3 cases of high-grade non-invasive neoplasia, indicating that these patients require strict endoscopic and bioptic follow-up. Conclusion: A regional Barrett's Oeosphagus Registry is feasible at a relatively low cost and enables significant data to be collected in a relatively short time. The use of a standardised endoscopic nomenclature and report form, a strict biopsy protocol, a standard report for pathologists improves the quality of endoscopic and histological diagnoses.

Original languageEnglish
Pages (from-to)18-25
Number of pages8
JournalDigestive and Liver Disease
Volume39
Issue number1
DOIs
Publication statusPublished - Jan 2007

Fingerprint

Barrett Esophagus
Registries
Neoplasms
Adenocarcinoma
Biopsy
Endoscopy
Incidence
Natural History
Terminology
Technology
Costs and Cost Analysis

Keywords

  • Barrett's Oesophagus
  • Non-invasive neoplasia
  • Registry

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Zaninotto, G., Minnei, F., Guirroli, E., Ceolin, M., Battaglia, G., Bellumat, A., ... Rugge, M. (2007). The Veneto Region's Barrett's Oesophagus Registry: Aims, methods, preliminary results. Digestive and Liver Disease, 39(1), 18-25. https://doi.org/10.1016/j.dld.2006.09.021

The Veneto Region's Barrett's Oesophagus Registry : Aims, methods, preliminary results. / Zaninotto, G.; Minnei, F.; Guirroli, E.; Ceolin, M.; Battaglia, G.; Bellumat, A.; Betetto, G.; Bozzola, L.; Cassaro, M.; Cataudella, G.; Dal Bò, N.; Farinati, F.; Florea, G.; Furlanetto, A.; Galliani, E.; Germanà, B.; Guerini, A.; Macrì, E.; Marcon, V.; Mastropaolo, G.; Meggio, A.; Miori, G.; Morelli, L.; Murer, B.; Norberto, L.; Togni, R.; Valiante, F.; Rugge, M.

In: Digestive and Liver Disease, Vol. 39, No. 1, 01.2007, p. 18-25.

Research output: Contribution to journalArticle

Zaninotto, G, Minnei, F, Guirroli, E, Ceolin, M, Battaglia, G, Bellumat, A, Betetto, G, Bozzola, L, Cassaro, M, Cataudella, G, Dal Bò, N, Farinati, F, Florea, G, Furlanetto, A, Galliani, E, Germanà, B, Guerini, A, Macrì, E, Marcon, V, Mastropaolo, G, Meggio, A, Miori, G, Morelli, L, Murer, B, Norberto, L, Togni, R, Valiante, F & Rugge, M 2007, 'The Veneto Region's Barrett's Oesophagus Registry: Aims, methods, preliminary results', Digestive and Liver Disease, vol. 39, no. 1, pp. 18-25. https://doi.org/10.1016/j.dld.2006.09.021
Zaninotto G, Minnei F, Guirroli E, Ceolin M, Battaglia G, Bellumat A et al. The Veneto Region's Barrett's Oesophagus Registry: Aims, methods, preliminary results. Digestive and Liver Disease. 2007 Jan;39(1):18-25. https://doi.org/10.1016/j.dld.2006.09.021
Zaninotto, G. ; Minnei, F. ; Guirroli, E. ; Ceolin, M. ; Battaglia, G. ; Bellumat, A. ; Betetto, G. ; Bozzola, L. ; Cassaro, M. ; Cataudella, G. ; Dal Bò, N. ; Farinati, F. ; Florea, G. ; Furlanetto, A. ; Galliani, E. ; Germanà, B. ; Guerini, A. ; Macrì, E. ; Marcon, V. ; Mastropaolo, G. ; Meggio, A. ; Miori, G. ; Morelli, L. ; Murer, B. ; Norberto, L. ; Togni, R. ; Valiante, F. ; Rugge, M. / The Veneto Region's Barrett's Oesophagus Registry : Aims, methods, preliminary results. In: Digestive and Liver Disease. 2007 ; Vol. 39, No. 1. pp. 18-25.
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TY - JOUR

T1 - The Veneto Region's Barrett's Oesophagus Registry

T2 - Aims, methods, preliminary results

AU - Zaninotto, G.

AU - Minnei, F.

AU - Guirroli, E.

AU - Ceolin, M.

AU - Battaglia, G.

AU - Bellumat, A.

AU - Betetto, G.

AU - Bozzola, L.

AU - Cassaro, M.

AU - Cataudella, G.

AU - Dal Bò, N.

AU - Farinati, F.

AU - Florea, G.

AU - Furlanetto, A.

AU - Galliani, E.

AU - Germanà, B.

AU - Guerini, A.

AU - Macrì, E.

AU - Marcon, V.

AU - Mastropaolo, G.

AU - Meggio, A.

AU - Miori, G.

AU - Morelli, L.

AU - Murer, B.

AU - Norberto, L.

AU - Togni, R.

AU - Valiante, F.

AU - Rugge, M.

PY - 2007/1

Y1 - 2007/1

N2 - Background: The natural history of Barrett's Oeosphagus is not completely clarified and Barrett's Oeosphagus Registries are considered useful tools to expand our knowledge on this disease. A Barrett's Oeosphagus Registry has been therefore established in the Veneto Region and neighbouring provinces. Aims: The aims of the Registry are to assess the demographical, endoscopical and histological characteristics of Barrett's Oeosphagus patients; the prevalence of non-invasive neoplasia and Barrett's Adenocarcinoma and the timing and incidence of Barrett's Oeosphagus progression to malignancy. Methods: An interdisciplinary committee of endoscopists, pathologists and information technology experts was established in 2004 to design a website-based Barrett's Oesophagus Registry for the Veneto Region and neighbouring north-eastern Italian provinces. Protocols for endoscopies and biopsies and standard reports were carefully defined. Results: In the first 18 months, 397 patients with endoscopically visible and histologically proven Barrett's Oeosphagus were enrolled in the Registry; the median age of these patients was 66 years (male:female = 3:1). Most patients (75%) had a Short Segment of Barrett's Oesophagus (≤3 cm) and only 1 in 4 had a Long Segment of Barrett's Oesophagus (>3 cm). Long Segment of Barrett's Oesophagus patients were 5 years older than the Short Segment of Barrett's Oesophagus patients (p <0.05), suggesting a progression from Short Segment of Barrett's Oesophagus to Long Segment of Barrett's Oesophagus. Though no data are available on the incidence of non-invasive neoplasia or Barrett's Adenocarcinoma (i.e., progression to cancer at least 12 months after enrolment), the prevalence of neoplastic lesions (found within 12 months of enrolment) was 5% for Short Segment of Barrett's Oesophagus and 19% for Long Segment of Barrett's Oesophagus, indicating that a careful multiple-biopsy endoscopic protocol is needed, especially when Long Segment of Barrett's Oesophagus are suspected at endoscopy. The prevalence of Barrett's Adenocarcinoma among patients with non-invasive neoplasia was 1/17 cases of low-grade non-invasive neoplasia and 2/3 cases of high-grade non-invasive neoplasia, indicating that these patients require strict endoscopic and bioptic follow-up. Conclusion: A regional Barrett's Oeosphagus Registry is feasible at a relatively low cost and enables significant data to be collected in a relatively short time. The use of a standardised endoscopic nomenclature and report form, a strict biopsy protocol, a standard report for pathologists improves the quality of endoscopic and histological diagnoses.

AB - Background: The natural history of Barrett's Oeosphagus is not completely clarified and Barrett's Oeosphagus Registries are considered useful tools to expand our knowledge on this disease. A Barrett's Oeosphagus Registry has been therefore established in the Veneto Region and neighbouring provinces. Aims: The aims of the Registry are to assess the demographical, endoscopical and histological characteristics of Barrett's Oeosphagus patients; the prevalence of non-invasive neoplasia and Barrett's Adenocarcinoma and the timing and incidence of Barrett's Oeosphagus progression to malignancy. Methods: An interdisciplinary committee of endoscopists, pathologists and information technology experts was established in 2004 to design a website-based Barrett's Oesophagus Registry for the Veneto Region and neighbouring north-eastern Italian provinces. Protocols for endoscopies and biopsies and standard reports were carefully defined. Results: In the first 18 months, 397 patients with endoscopically visible and histologically proven Barrett's Oeosphagus were enrolled in the Registry; the median age of these patients was 66 years (male:female = 3:1). Most patients (75%) had a Short Segment of Barrett's Oesophagus (≤3 cm) and only 1 in 4 had a Long Segment of Barrett's Oesophagus (>3 cm). Long Segment of Barrett's Oesophagus patients were 5 years older than the Short Segment of Barrett's Oesophagus patients (p <0.05), suggesting a progression from Short Segment of Barrett's Oesophagus to Long Segment of Barrett's Oesophagus. Though no data are available on the incidence of non-invasive neoplasia or Barrett's Adenocarcinoma (i.e., progression to cancer at least 12 months after enrolment), the prevalence of neoplastic lesions (found within 12 months of enrolment) was 5% for Short Segment of Barrett's Oesophagus and 19% for Long Segment of Barrett's Oesophagus, indicating that a careful multiple-biopsy endoscopic protocol is needed, especially when Long Segment of Barrett's Oesophagus are suspected at endoscopy. The prevalence of Barrett's Adenocarcinoma among patients with non-invasive neoplasia was 1/17 cases of low-grade non-invasive neoplasia and 2/3 cases of high-grade non-invasive neoplasia, indicating that these patients require strict endoscopic and bioptic follow-up. Conclusion: A regional Barrett's Oeosphagus Registry is feasible at a relatively low cost and enables significant data to be collected in a relatively short time. The use of a standardised endoscopic nomenclature and report form, a strict biopsy protocol, a standard report for pathologists improves the quality of endoscopic and histological diagnoses.

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