The vicious circle of treatment-induced toxicities in locally advanced head and neck cancer and the impact on treatment intensity

Bossi Paolo, Cossu Rocca Maria, Corvò Renzo, Depenni Roberta, Guardamagna Vittorio, Marinangeli Franco, Miccichè Francesco, Trippa Fabio

Research output: Contribution to journalReview article

Abstract

The intensity of the available treatment approaches for locally-advanced head and neck cancer (HNC) is at the upper limit of tolerance of acute toxicities. Several factors including breakthrough cancer pain, mucositis, dysphagia, local and systemic infections, and nutritional problems are related to treatment intensity. Particularly, pain, as symptom directly associated with the disease or combined with other treatment-related factors, has a major impact on quality of life of HNC patients and ultimately can influence the efficacy of treatments in HNC. Here, a Multidisciplinary Board of Italian Experts has addressed these issues, with the aim to identify the unmet need and appropriate strategies for the maintenance of optimal treatment intensity in HNC.

Original languageEnglish
Pages (from-to)82-88
Number of pages7
JournalCritical Reviews in Oncology/Hematology
Volume116
DOIs
Publication statusPublished - Aug 1 2017

Keywords

  • Breakthrough cancer pain
  • Concurrent chemoradiotherapy
  • Dysphagia
  • Head and neck cancer
  • Mucositis
  • Quality of life
  • Treatment intensity

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Geriatrics and Gerontology

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