The vitamin k-antagonism of salicylate and warfarin

M. C. Roncaglioni, M. M W Ulrich, A. D. Muller, B. A M Soute, M. A G de Boer-van den Berg, C. Vermeer

Research output: Contribution to journalArticlepeer-review

Abstract

When administered in high dosages, salicylate acts as a vitamin K-antagonist: it induces a decrease of the plasma concentration of the Gla-containing coagulation factors and an accumulation of microsomal substrates for vitamin K-dependent carboxylase in the liver and in the lung. In vitro the drugs inhibit the DTT-dependent reductases which mediate the reduction of vitamin K epoxide and vitamin K quinone. NADH-dependent reductase and vitamin K-dependent carboxylase are not inhibited.

Original languageEnglish
Pages (from-to)727-736
Number of pages10
JournalThrombosis Research
Volume42
Issue number6
DOIs
Publication statusPublished - Jun 15 1986

Keywords

  • -carboxyglutamic acid
  • carboxylase
  • reductase salicylate
  • Vitamin K
  • warfarin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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