The weight of leptin in immunity

Antonio La Cava, Giuseppe Matarese

Research output: Contribution to journalArticle

574 Citations (Scopus)

Abstract

Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. As a hormone, leptin regulates food intake and basal metabolism, and is sexually dimorphic - that is, its serum concentration is higher in females than in males with a similar body fat mass. As a cytokine, leptin can affect thymic homeostasis and the secretion of acute-phase reactants such as interleukin-1 and tumour-necrosis factor. Similar to other pro-inflammatory cytokines, leptin promotes T helper 1 (T H1)-cell differentiation and can modulate the onset and progression of autoimmune responses in several animal models of disease. Here, we review the advances and controversy for a role of leptin in the pathophysiology of immune responses.

Original languageEnglish
Pages (from-to)371-379
Number of pages9
JournalNature Reviews Immunology
Volume4
Issue number5
Publication statusPublished - May 2004

Fingerprint

Leptin
Immunity
Weights and Measures
Cytokines
Hormones
Animal Disease Models
Basal Metabolism
Th1 Cells
Acute-Phase Proteins
Nutritional Status
Autoimmunity
Interleukin-1
Adipocytes
Adipose Tissue
Cell Differentiation
Homeostasis
Tumor Necrosis Factor-alpha
Eating
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

La Cava, A., & Matarese, G. (2004). The weight of leptin in immunity. Nature Reviews Immunology, 4(5), 371-379.

The weight of leptin in immunity. / La Cava, Antonio; Matarese, Giuseppe.

In: Nature Reviews Immunology, Vol. 4, No. 5, 05.2004, p. 371-379.

Research output: Contribution to journalArticle

La Cava, A & Matarese, G 2004, 'The weight of leptin in immunity', Nature Reviews Immunology, vol. 4, no. 5, pp. 371-379.
La Cava A, Matarese G. The weight of leptin in immunity. Nature Reviews Immunology. 2004 May;4(5):371-379.
La Cava, Antonio ; Matarese, Giuseppe. / The weight of leptin in immunity. In: Nature Reviews Immunology. 2004 ; Vol. 4, No. 5. pp. 371-379.
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