The weight of leptin in immunity

Antonio La Cava, Giuseppe Matarese

Research output: Contribution to journalArticle

Abstract

Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. As a hormone, leptin regulates food intake and basal metabolism, and is sexually dimorphic - that is, its serum concentration is higher in females than in males with a similar body fat mass. As a cytokine, leptin can affect thymic homeostasis and the secretion of acute-phase reactants such as interleukin-1 and tumour-necrosis factor. Similar to other pro-inflammatory cytokines, leptin promotes T helper 1 (T H1)-cell differentiation and can modulate the onset and progression of autoimmune responses in several animal models of disease. Here, we review the advances and controversy for a role of leptin in the pathophysiology of immune responses.

Original languageEnglish
Pages (from-to)371-379
Number of pages9
JournalNature Reviews Immunology
Volume4
Issue number5
Publication statusPublished - May 2004

ASJC Scopus subject areas

  • Immunology

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  • Cite this

    La Cava, A., & Matarese, G. (2004). The weight of leptin in immunity. Nature Reviews Immunology, 4(5), 371-379.