The wnt pathway in mood disorders

Gabriele Sani, Flavia Napoletano, Alberto Maria Forte, Giorgio D. Kotzalidis, Isabella Panaccione, Giulio Maria Porfiri, Alessio Simonetti, Matteo Caloro, Nicoletta Girardi, Carla Ludovica Telesforo, Giulia Serra, Silvia Romano, Giovanni Manfredi, Valeria Savoja, Stefano Maria Tamorri, Alexia E. Koukopoulos, Daniele Serata, Chiara Rapinesi, Antonio Del Casale, Ferdinando NicolettiPaolo Girardi

Research output: Contribution to journalArticlepeer-review


Objectives: To review the evidence of the involvement of the Wnt signalling pathway in mood disorders and in the action of drugs used to treat these disorders. Methods: We performed a careful PubMed search using as keywords all possible terms relevant to the Wnt pathway and crossing them with each of four areas, i.e., developmental effects, behavioural effects, mood disorders, and drugs used in their treatment. Papers were selected on the basis of their content and their data used for discussion. Results: Neurodevelopmental and behavioural data point to the possibility of involvement of the Wnt pathway in the pathophysiology of mood disorders. Clinical and post-mortem data are not sufficient to corroborate a definite role for Wnt alterations in any mood disorder. Combining genetic and pharmacological data, we may state that glycogen synthase kinase is the key molecule in bipolar disorder, as it is connected with many other signalling pathways that were shown to be involved in mood disorders, while Wnt molecules in the hippocampus appear to be mainly involved in depressive disorders. Conclusions: Altered Wnt signalling may play a role in the pathophysiology of mood disorders, although not a central one. It is premature to draw conclusions regarding the possible usefulness of Wnt manipulations in the treatment of mood disorders.

Original languageEnglish
Pages (from-to)239-253
Number of pages15
JournalCurrent Neuropharmacology
Issue number3
Publication statusPublished - 2012


  • Antidepressant Drugs
  • Antipsychotic Drugs
  • Bipolar Disorder
  • Major Depression
  • Mood Disorders
  • Mood Stabilising Agents
  • Wingless (Wnt) signalling

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Pharmacology
  • Neurology
  • Psychiatry and Mental health


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