Abstract
Background. Although the incidence of sudden cardiac death (SCD) is high among haemodialysis (HD) patients, there are few papers available on this topic. The aim of this study on a single-centre HD population observed over a 10 year period was to identify patient- and HD-related specific factors that might be associated with a higher risk of SCD. Methods. The study included 123 patients (76 men; age 29-79 years) undergoing renal replacement therapy at our dialysis unit for at least 6 months. For each patient, routine laboratory tests were performed monthly, blood pressure was measured both at the start and the end of each dialysis session, haemoglobin and pre-dialysis serum K+ were determined weekly, serum iPTH was assessed thrice yearly, and an echocardiographic study was performed annually to determine the left ventricular mass index (LVMi). The prevalence of cardiovascular (CV) co-morbidities, and the incidence of new events were also recorded. Results. During the 10 years, 85 patients died - 16 from SCD, 30 from cardiac causes (CC) other than SCD, and 39 from other causes (OC); 38 patients were still alive (AL) at the end of the observation period. Comparative analysis of SCD, CC, OC and AL, reveals that the male prevalence (13/3) was higher in SCD than in AL, while AL were younger than the deceased patients regardless of the cause of death (P2 body surface area] compared with OC (-5±35), AL (-17±25) and even CC (7±30) (P<0.0001; ANOVA); finally, the prevalence of patients with ischaemic heart disease (IHD) was higher in the SCD group (11/5; P2). Univariate Cox regression analysis demonstrated that the factors increasing the risk of SCD were IHD (P=0.002), the worsening of left ventricular hypertrophy (LVH) (P
| Original language | English |
|---|---|
| Pages (from-to) | 1829-1834 |
| Number of pages | 6 |
| Journal | Nephrology Dialysis Transplantation |
| Volume | 19 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jun 2004 |
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Keywords
- Haemodialysis
- Left ventricular hypertrophy
- Sudden cardiac death
ASJC Scopus subject areas
- Nephrology
- Transplantation
Cite this
The worsening of left ventricular hypertrophy is the strongest predictor of sudden cardiac death in haemodialysis patients : A 10 year survey. / Paoletti, Ernesto; Specchia, Claudia; Di Maio, Giovanni; Bellino, Diego; Damasio, Beatrice; Cassottana, Paolo; Cannella, Giuseppe.
In: Nephrology Dialysis Transplantation, Vol. 19, No. 7, 06.2004, p. 1829-1834.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The worsening of left ventricular hypertrophy is the strongest predictor of sudden cardiac death in haemodialysis patients
T2 - A 10 year survey
AU - Paoletti, Ernesto
AU - Specchia, Claudia
AU - Di Maio, Giovanni
AU - Bellino, Diego
AU - Damasio, Beatrice
AU - Cassottana, Paolo
AU - Cannella, Giuseppe
PY - 2004/6
Y1 - 2004/6
N2 - Background. Although the incidence of sudden cardiac death (SCD) is high among haemodialysis (HD) patients, there are few papers available on this topic. The aim of this study on a single-centre HD population observed over a 10 year period was to identify patient- and HD-related specific factors that might be associated with a higher risk of SCD. Methods. The study included 123 patients (76 men; age 29-79 years) undergoing renal replacement therapy at our dialysis unit for at least 6 months. For each patient, routine laboratory tests were performed monthly, blood pressure was measured both at the start and the end of each dialysis session, haemoglobin and pre-dialysis serum K+ were determined weekly, serum iPTH was assessed thrice yearly, and an echocardiographic study was performed annually to determine the left ventricular mass index (LVMi). The prevalence of cardiovascular (CV) co-morbidities, and the incidence of new events were also recorded. Results. During the 10 years, 85 patients died - 16 from SCD, 30 from cardiac causes (CC) other than SCD, and 39 from other causes (OC); 38 patients were still alive (AL) at the end of the observation period. Comparative analysis of SCD, CC, OC and AL, reveals that the male prevalence (13/3) was higher in SCD than in AL, while AL were younger than the deceased patients regardless of the cause of death (P2 body surface area] compared with OC (-5±35), AL (-17±25) and even CC (7±30) (P<0.0001; ANOVA); finally, the prevalence of patients with ischaemic heart disease (IHD) was higher in the SCD group (11/5; P2). Univariate Cox regression analysis demonstrated that the factors increasing the risk of SCD were IHD (P=0.002), the worsening of left ventricular hypertrophy (LVH) (P
AB - Background. Although the incidence of sudden cardiac death (SCD) is high among haemodialysis (HD) patients, there are few papers available on this topic. The aim of this study on a single-centre HD population observed over a 10 year period was to identify patient- and HD-related specific factors that might be associated with a higher risk of SCD. Methods. The study included 123 patients (76 men; age 29-79 years) undergoing renal replacement therapy at our dialysis unit for at least 6 months. For each patient, routine laboratory tests were performed monthly, blood pressure was measured both at the start and the end of each dialysis session, haemoglobin and pre-dialysis serum K+ were determined weekly, serum iPTH was assessed thrice yearly, and an echocardiographic study was performed annually to determine the left ventricular mass index (LVMi). The prevalence of cardiovascular (CV) co-morbidities, and the incidence of new events were also recorded. Results. During the 10 years, 85 patients died - 16 from SCD, 30 from cardiac causes (CC) other than SCD, and 39 from other causes (OC); 38 patients were still alive (AL) at the end of the observation period. Comparative analysis of SCD, CC, OC and AL, reveals that the male prevalence (13/3) was higher in SCD than in AL, while AL were younger than the deceased patients regardless of the cause of death (P2 body surface area] compared with OC (-5±35), AL (-17±25) and even CC (7±30) (P<0.0001; ANOVA); finally, the prevalence of patients with ischaemic heart disease (IHD) was higher in the SCD group (11/5; P2). Univariate Cox regression analysis demonstrated that the factors increasing the risk of SCD were IHD (P=0.002), the worsening of left ventricular hypertrophy (LVH) (P
KW - Haemodialysis
KW - Left ventricular hypertrophy
KW - Sudden cardiac death
UR - http://www.scopus.com/inward/record.url?scp=3242666899&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3242666899&partnerID=8YFLogxK
U2 - 10.1093/ndt/gfh288
DO - 10.1093/ndt/gfh288
M3 - Article
C2 - 15128888
AN - SCOPUS:3242666899
VL - 19
SP - 1829
EP - 1834
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
SN - 0931-0509
IS - 7
ER -