TY - GEN
T1 - The X chromosome in female-predominant autoimmune diseases
AU - Invernizzi, Pietro
PY - 2007/9
Y1 - 2007/9
N2 - Autoimmune diseases affect approximately 5% of the population in Western countries, with high female predominance. Family and twins studies have demonstrated that genetic factors are crucial determinants of susceptibility to autoimmune disease, but no specific genes have yet been identified. Recent studies indicate that X chromosome abnormalities, such as monosomy rates and inactivation patterns, occur in a number of female-predominant autoimmune diseases. We will review herein the most recent evidence on the role of the X chromosome in loss of tolerance and discuss its potential implications. Future studies will identify the X chromosome regions containing candidate genes for autoimmune susceptibility.
AB - Autoimmune diseases affect approximately 5% of the population in Western countries, with high female predominance. Family and twins studies have demonstrated that genetic factors are crucial determinants of susceptibility to autoimmune disease, but no specific genes have yet been identified. Recent studies indicate that X chromosome abnormalities, such as monosomy rates and inactivation patterns, occur in a number of female-predominant autoimmune diseases. We will review herein the most recent evidence on the role of the X chromosome in loss of tolerance and discuss its potential implications. Future studies will identify the X chromosome regions containing candidate genes for autoimmune susceptibility.
KW - Autoimmunity
KW - Immunopathogenesis
KW - Monosomy
KW - X chromosome
KW - X chromosome inactivation
UR - http://www.scopus.com/inward/record.url?scp=35748975958&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35748975958&partnerID=8YFLogxK
U2 - 10.1196/annals.1423.007
DO - 10.1196/annals.1423.007
M3 - Conference contribution
C2 - 17911420
AN - SCOPUS:35748975958
SN - 1573317098
SN - 9781573317092
VL - 1110
T3 - Annals of the New York Academy of Sciences
SP - 57
EP - 64
BT - Annals of the New York Academy of Sciences
ER -