Emergenza XDR-TB: Le risposte della comunità scientifica

Translated title of the contribution: The XDR-TB emergency: Answers from the scientific community

Giovanni Battista Migliori, Rosella Centis, Lia D'Ambrosio, Giorgio Besozzi, Giovanni Sotgiu

Research output: Contribution to journalArticlepeer-review


Extensively drug-resistant tuberculosis (XDR-TB) is a global problem and represents a serious challenge for public health and clinical management. Laboratory diagnosis is difficult and little evidence exists to guide clinicians in treating people with XDR-TB effectively. To summarize the available data on XDR-TB, we performed a review on 12 recent studies focusing on the epidemiology and clinical management of XDR-TB. Methods. Studies that met inclusion criteria were reviewed to assess methodology, treatment regimens, and treatment outcomes. Results. XDR-TB can be successfully treated in up to 65% of patients, particularly those who are not co-infected with HIV. However, treatment duration is longer and outcomes are in general poorer than for non-XDR-TB patients. Conclusion. Future studies should fulfil the following criteria: i) be prospective in design, ii) adopt standardized, internationally accepted definitions, iii) use quality-assured laboratory testing for all first- and second-line drugs, and iv) collect data on an agreed-upon set of standard variables allowing for comparisons across studies. Early diagnosis and aggressive management of XDR-TB increase the chance of a positive outcome, although prevention is still a key objective of any national TB programme.

Translated title of the contributionThe XDR-TB emergency: Answers from the scientific community
Original languageItalian
Pages (from-to)319-324
Number of pages6
JournalRassegna di Patologia dell'Apparato Respiratorio
Issue number5
Publication statusPublished - Oct 2009

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pulmonary and Respiratory Medicine


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