The yield of subtelomeric FISH analysis in the evaluation of autistic spectrum disorders

Agatino Battaglia, Maria C. Bonaglia

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To assess the frequency of cryptic subtelomeric rearrangements in children and adolescents with autism spectrum disorders, blood samples were studied using a complete set of subtelomeric FISH probes in 72 children with autism spectrum disorders. All children had normal high resolution karyotype, DNA fra-X analysis, brain MRI, metabolic work-up, and physical/neirological examination. Subtelomeric analysis did not detect abnormalities in any of the subjects, suggesting the uselessness of such investigations in individuals with primary autism spectrum disorders.

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalAmerican Journal of Medical Genetics, Part C: Seminars in Medical Genetics
Volume142 C
Issue number1
DOIs
Publication statusPublished - Feb 15 2006

Fingerprint

Autistic Disorder
Karyotype
Physical Examination
DNA
Brain
Autism Spectrum Disorder

Keywords

  • Autism
  • Autism spectrum disorders
  • Pervasive developmental disorders
  • Subtelomeric regions, subtelomeric FISH analysis
  • Telomere

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

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AB - To assess the frequency of cryptic subtelomeric rearrangements in children and adolescents with autism spectrum disorders, blood samples were studied using a complete set of subtelomeric FISH probes in 72 children with autism spectrum disorders. All children had normal high resolution karyotype, DNA fra-X analysis, brain MRI, metabolic work-up, and physical/neirological examination. Subtelomeric analysis did not detect abnormalities in any of the subjects, suggesting the uselessness of such investigations in individuals with primary autism spectrum disorders.

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