The Yin and Yang of CD4 + regulatory T cells in autoimmunity and cancer

M. Galgani, A. Di Giacomo, G. Matarese, A. La Cava

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The immune system balances effector responses with tolerance, to protect the host from pathogens while minimizing local damage to tissue. An altered control of immune homeostasis can lead to loss of tolerance to self antigens in autoimmunity, or promote unwanted tolerance to tumor growth. This review focuses on the dual activity of CD4 + regulatory T cells (Tregs) in autoimmunity and cancer. Tregs play a key role in the mechanisms of immune tolerance and actively suppress pro-inflammatory responses, thus providing a beneficial action in autoimmunity and detrimental effects in cancer.

Original languageEnglish
Pages (from-to)4626-4631
Number of pages6
JournalCurrent Medicinal Chemistry
Volume16
Issue number35
DOIs
Publication statusPublished - 2009

Fingerprint

Yin-Yang
T-cells
Regulatory T-Lymphocytes
Autoimmunity
Neoplasms
Immune Tolerance
Autoantigens
Immune system
Immune System
Homeostasis
Pathogens
Tumors
Tissue
Growth

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

The Yin and Yang of CD4 + regulatory T cells in autoimmunity and cancer. / Galgani, M.; Di Giacomo, A.; Matarese, G.; La Cava, A.

In: Current Medicinal Chemistry, Vol. 16, No. 35, 2009, p. 4626-4631.

Research output: Contribution to journalArticle

Galgani, M, Di Giacomo, A, Matarese, G & La Cava, A 2009, 'The Yin and Yang of CD4 + regulatory T cells in autoimmunity and cancer', Current Medicinal Chemistry, vol. 16, no. 35, pp. 4626-4631. https://doi.org/10.2174/092986709789878201
Galgani, M. ; Di Giacomo, A. ; Matarese, G. ; La Cava, A. / The Yin and Yang of CD4 + regulatory T cells in autoimmunity and cancer. In: Current Medicinal Chemistry. 2009 ; Vol. 16, No. 35. pp. 4626-4631.
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