The yin and yang of intestinal epithelial cells in controlling dendritic cell function

Iliyan D. Iliev, Gianluca Matteoli, Maria Rescigno

Research output: Contribution to journalArticlepeer-review

Abstract

Recent work suggests that dendritic cells (DCs) in mucosal tissues are "educated" by intestinal epithelial cells (IECs) to suppress inflammation and promote immunological tolerance. After attack by pathogenic microorganisms, however, "non-educated" DCs are recruited from nearby areas, such as the dome of Peyer's patches (PPs) and the blood, to initiate inflammation and the ensuing immune response to the invader. Differential epithelial cell (EC) responses to commensals and pathogens may control these two tolorogenic and immunogenic functions of DCs. JEM

Original languageEnglish
Pages (from-to)2253-2257
Number of pages5
JournalJournal of Experimental Medicine
Volume204
Issue number10
DOIs
Publication statusPublished - Oct 1 2007

ASJC Scopus subject areas

  • Immunology

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