The yin-yang of long pentraxin PTX3 in inflammation and immunity

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Pentraxins are a family of multimeric proteins characterized by the presence of a pentraxin signature in their C-terminus region. Based on the primary structure, pentraxins are divided into short and long pentraxin: C-reactive protein (CRP) is the prototype of the short pentraxin subfamily while pentraxin 3 (PTX3) is the prototypic long pentraxin. Despite these two molecules exert similar fundamental actions in the regulation of innate immune and inflammatory responses, several differences exist between CRP and PTX3, including gene organization, protein oligomerization and expression pattern. The pathophysiological roles of PTX3 have been investigated using genetically modified mice since PTX3 gene organization and regulation are well conserved between mouse and human. Such in vivo studies figured out that PTX3 mainly have host-protective effects, even if it could also exert negative effects under certain pathophysiologic conditions. Here we will review the general properties of CRP and PTX3, emphasizing the differences between the two molecules and the regulatory functions exerted by PTX3 in innate immunity and inflammation.

Original languageEnglish
Pages (from-to)38-43
Number of pages6
JournalImmunology Letters
Volume161
Issue number1
DOIs
Publication statusPublished - 2014

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Yin-Yang
Immunity
Inflammation
C-Reactive Protein
Innate Immunity
PTX3 protein
Proteins

Keywords

  • Inflammation
  • Innate immunity
  • Pentraxin
  • PTX3

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

The yin-yang of long pentraxin PTX3 in inflammation and immunity. / Daigo, Kenji; Mantovani, Alberto; Bottazzi, Barbara.

In: Immunology Letters, Vol. 161, No. 1, 2014, p. 38-43.

Research output: Contribution to journalArticle

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