The yin-yang of the interaction between myelomonocytic cells and NK cells

Research output: Contribution to journalReview article

Abstract

NK cells are innate lymphoid cells, which play a key role in the immune response to cancer and pathogens and participate in the shaping of adaptive immunity. NK cells engage in a complex bidirectional interaction with myelomonocytic cells. In particular, macrophages, dendritic cells and neutrophils promote differentiation and effector function of NK cells and, on the other hand, myelomonocytic cells express triggers of checkpoint blockade (eg PD-L1) and other immunosuppressive molecules, which negatively regulate NK cell function. In addition, NK cells express high levels of IL-1R8, which acts as a checkpoint for IL-18 driven differentiation and activation of NK cells. Evidence suggests that targeting the myeloid cell-NK cell crosstalk unleashes effective anti-tumour and anti-viral resistance.

Original languageEnglish
Pages (from-to)e12705
JournalScandinavian Journal of Immunology
Volume88
Issue number3
DOIs
Publication statusPublished - Sep 2018

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Yin-Yang
Natural Killer Cells
Interleukin-18
Adaptive Immunity
Myeloid Cells
Immunosuppressive Agents
Dendritic Cells
Neoplasms
Neutrophils
Macrophages
Lymphocytes

Keywords

  • Animals
  • B7-H1 Antigen/metabolism
  • Cell Communication
  • Humans
  • Immunity, Innate
  • Interleukin-18/metabolism
  • Killer Cells, Natural/physiology
  • Myeloid Cells/physiology
  • Neoplasms/immunology
  • Receptors, Interleukin-1/metabolism
  • Virus Diseases/immunology
  • Yin-Yang

Cite this

@article{66f196410b5844b2864d65370a26b496,
title = "The yin-yang of the interaction between myelomonocytic cells and NK cells",
abstract = "NK cells are innate lymphoid cells, which play a key role in the immune response to cancer and pathogens and participate in the shaping of adaptive immunity. NK cells engage in a complex bidirectional interaction with myelomonocytic cells. In particular, macrophages, dendritic cells and neutrophils promote differentiation and effector function of NK cells and, on the other hand, myelomonocytic cells express triggers of checkpoint blockade (eg PD-L1) and other immunosuppressive molecules, which negatively regulate NK cell function. In addition, NK cells express high levels of IL-1R8, which acts as a checkpoint for IL-18 driven differentiation and activation of NK cells. Evidence suggests that targeting the myeloid cell-NK cell crosstalk unleashes effective anti-tumour and anti-viral resistance.",
keywords = "Animals, B7-H1 Antigen/metabolism, Cell Communication, Humans, Immunity, Innate, Interleukin-18/metabolism, Killer Cells, Natural/physiology, Myeloid Cells/physiology, Neoplasms/immunology, Receptors, Interleukin-1/metabolism, Virus Diseases/immunology, Yin-Yang",
author = "Martina Molgora and Domenico Supino and Domenico Mavilio and Angela Santoni and Lorenzo Moretta and Alberto Mantovani and Cecilia Garlanda",
note = "{\circledC} 2018 The Foundation for the Scandinavian Journal of Immunology.",
year = "2018",
month = "9",
doi = "10.1111/sji.12705",
language = "English",
volume = "88",
pages = "e12705",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - The yin-yang of the interaction between myelomonocytic cells and NK cells

AU - Molgora, Martina

AU - Supino, Domenico

AU - Mavilio, Domenico

AU - Santoni, Angela

AU - Moretta, Lorenzo

AU - Mantovani, Alberto

AU - Garlanda, Cecilia

N1 - © 2018 The Foundation for the Scandinavian Journal of Immunology.

PY - 2018/9

Y1 - 2018/9

N2 - NK cells are innate lymphoid cells, which play a key role in the immune response to cancer and pathogens and participate in the shaping of adaptive immunity. NK cells engage in a complex bidirectional interaction with myelomonocytic cells. In particular, macrophages, dendritic cells and neutrophils promote differentiation and effector function of NK cells and, on the other hand, myelomonocytic cells express triggers of checkpoint blockade (eg PD-L1) and other immunosuppressive molecules, which negatively regulate NK cell function. In addition, NK cells express high levels of IL-1R8, which acts as a checkpoint for IL-18 driven differentiation and activation of NK cells. Evidence suggests that targeting the myeloid cell-NK cell crosstalk unleashes effective anti-tumour and anti-viral resistance.

AB - NK cells are innate lymphoid cells, which play a key role in the immune response to cancer and pathogens and participate in the shaping of adaptive immunity. NK cells engage in a complex bidirectional interaction with myelomonocytic cells. In particular, macrophages, dendritic cells and neutrophils promote differentiation and effector function of NK cells and, on the other hand, myelomonocytic cells express triggers of checkpoint blockade (eg PD-L1) and other immunosuppressive molecules, which negatively regulate NK cell function. In addition, NK cells express high levels of IL-1R8, which acts as a checkpoint for IL-18 driven differentiation and activation of NK cells. Evidence suggests that targeting the myeloid cell-NK cell crosstalk unleashes effective anti-tumour and anti-viral resistance.

KW - Animals

KW - B7-H1 Antigen/metabolism

KW - Cell Communication

KW - Humans

KW - Immunity, Innate

KW - Interleukin-18/metabolism

KW - Killer Cells, Natural/physiology

KW - Myeloid Cells/physiology

KW - Neoplasms/immunology

KW - Receptors, Interleukin-1/metabolism

KW - Virus Diseases/immunology

KW - Yin-Yang

U2 - 10.1111/sji.12705

DO - 10.1111/sji.12705

M3 - Review article

C2 - 30048003

VL - 88

SP - e12705

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

SN - 0300-9475

IS - 3

ER -