The yin-yang of the interaction between myelomonocytic cells and NK cells

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Abstract

NK cells are innate lymphoid cells, which play a key role in the immune response to cancer and pathogens and participate in the shaping of adaptive immunity. NK cells engage in a complex bidirectional interaction with myelomonocytic cells. In particular, macrophages, dendritic cells and neutrophils promote differentiation and effector function of NK cells and, on the other hand, myelomonocytic cells express triggers of checkpoint blockade (eg PD-L1) and other immunosuppressive molecules, which negatively regulate NK cell function. In addition, NK cells express high levels of IL-1R8, which acts as a checkpoint for IL-18 driven differentiation and activation of NK cells. Evidence suggests that targeting the myeloid cell-NK cell crosstalk unleashes effective anti-tumour and anti-viral resistance.
Original languageEnglish
Pages (from-to)e12705
JournalScandinavian Journal of Immunology
Volume88
Issue number3
DOIs
Publication statusPublished - Sep 2018

Keywords

  • Animals
  • B7-H1 Antigen/metabolism
  • Cell Communication
  • Humans
  • Immunity, Innate
  • Interleukin-18/metabolism
  • Killer Cells, Natural/physiology
  • Myeloid Cells/physiology
  • Neoplasms/immunology
  • Receptors, Interleukin-1/metabolism
  • Virus Diseases/immunology
  • Yin-Yang

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