The yin-yang of the interaction between myelomonocytic cells and NK cells

Research output: Contribution to journalArticlepeer-review


NK cells are innate lymphoid cells, which play a key role in the immune response to cancer and pathogens and participate in the shaping of adaptive immunity. NK cells engage in a complex bidirectional interaction with myelomonocytic cells. In particular, macrophages, dendritic cells and neutrophils promote differentiation and effector function of NK cells and, on the other hand, myelomonocytic cells express triggers of checkpoint blockade (eg PD-L1) and other immunosuppressive molecules, which negatively regulate NK cell function. In addition, NK cells express high levels of IL-1R8, which acts as a checkpoint for IL-18 driven differentiation and activation of NK cells. Evidence suggests that targeting the myeloid cell-NK cell crosstalk unleashes effective anti-tumour and anti-viral resistance.
Original languageEnglish
Pages (from-to)e12705
JournalScandinavian Journal of Immunology
Issue number3
Publication statusPublished - Sep 2018


  • Animals
  • B7-H1 Antigen/metabolism
  • Cell Communication
  • Humans
  • Immunity, Innate
  • Interleukin-18/metabolism
  • Killer Cells, Natural/physiology
  • Myeloid Cells/physiology
  • Neoplasms/immunology
  • Receptors, Interleukin-1/metabolism
  • Virus Diseases/immunology
  • Yin-Yang


Dive into the research topics of 'The yin-yang of the interaction between myelomonocytic cells and NK cells'. Together they form a unique fingerprint.

Cite this