Theophylline distribution in the premature neonate

M. Bonati, R. Latini, G. Marra, B. M. Assael, R. Parini

Research output: Contribution to journalArticlepeer-review


Theophylline (T) tissue distribution was studied in 11 premature newborns treated with T for prematurity apnea, who had died from severe pathology. To investigate the pattern of distribution of T, in particular the role of the blood-brain barrier in this period of life, two animal species were employed (rat and guinea pig), differing widely in their postnatal development. T was administered to the animals acutely and chronically and the resulting data were compared to human findings. In human prematures no specific accumulation and a wide variety in tissue concentrations, as in tissue/blood ratios, were observed. In the rat, unlike the guinea pig, brain/blood ratios of T concentration declined as postnatal age rose, suggesting that development of the blood-brain barrier plays a major role.

Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalDevelopmental Pharmacology and Therapeutics
Issue number2
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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