Theoretical Modeling of Coagulation Management with Therapeutic Plasma or Prothrombin Complex Concentrate

Herbert Schöchl, Oliver Grottke, Ken Sutor, Kieron Dony, Martin Schreiber, Marco Ranucci, Peter W. Collins

Research output: Contribution to journalArticle

Abstract

Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between amounts of PCC or therapeutic plasma administered, and plasma levels of FII and AT. The model showed that PCC produces substantial increases in plasma levels of FII but only small changes in AT, increasing the FII:AT ratio. Therapeutic plasma was shown to have only modest effects on levels of FII or AT, unless high doses are used.

Original languageEnglish
Pages (from-to)1471-1474
Number of pages4
JournalAnesthesia and Analgesia
Volume125
Issue number5
DOIs
Publication statusPublished - Nov 1 2017

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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