Abstract
Adult stem cells represent the self-renewing progenitors of numerous body tissues, and they are currently classified according to their origin and differentiation ability. In recent years, the research on stem cells has expanded enormously and holds therapeutic promises for many patients suffering from currently disabling diseases. This paper focuses on the possible use of stem cells in the two main clinical settings in gastroenterology, i.e., hepatic and intestinal diseases, which have a strong impact on public health worldwide. Despite encouraging results obtained in both regenerative medicine and immune-mediated conditions, furthe0072 studies are needed to fully understand the biology of stem cells and carefully assess their putative oncogenic properties. Moreover, the research on stem cells arouses fervent ethical, social and political debate. The Italian Society of Gastroenterology sponsored a workshop on stem cells held in Verona during the XVI Congress of the Federation of Italian Societies of Digestive Diseases (March 6-9, 2010). Here, we report on the issues discussed, including liver and intestinal diseases that may benefit from stem cell therapy, the biology of hepatic and intestinal tissue repair, and stem cell usage in clinical trials.
| Original language | English |
|---|---|
| Pages (from-to) | 3870-3880 |
| Number of pages | 11 |
| Journal | World Journal of Gastroenterology |
| Volume | 17 |
| Issue number | 34 |
| DOIs | |
| Publication status | Published - Sep 14 2011 |
Fingerprint
Keywords
- Cell therapy
- Inflammatory bowel disease
- Liver disease
- Regenerative me-dicine
- Stem cells
ASJC Scopus subject areas
- Gastroenterology
Cite this
Therapeutic application of stem cells in gastroenterology : An up-date. / Burra, Patrizia; Bizzaro, Debora; Ciccocioppo, Rachele; Marra, Fabio; Piscaglia, Anna Chiara; Porretti, Laura; Gasbarrini, Antonio; Russo, Francesco Paolo.
In: World Journal of Gastroenterology, Vol. 17, No. 34, 14.09.2011, p. 3870-3880.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Therapeutic application of stem cells in gastroenterology
T2 - An up-date
AU - Burra, Patrizia
AU - Bizzaro, Debora
AU - Ciccocioppo, Rachele
AU - Marra, Fabio
AU - Piscaglia, Anna Chiara
AU - Porretti, Laura
AU - Gasbarrini, Antonio
AU - Russo, Francesco Paolo
PY - 2011/9/14
Y1 - 2011/9/14
N2 - Adult stem cells represent the self-renewing progenitors of numerous body tissues, and they are currently classified according to their origin and differentiation ability. In recent years, the research on stem cells has expanded enormously and holds therapeutic promises for many patients suffering from currently disabling diseases. This paper focuses on the possible use of stem cells in the two main clinical settings in gastroenterology, i.e., hepatic and intestinal diseases, which have a strong impact on public health worldwide. Despite encouraging results obtained in both regenerative medicine and immune-mediated conditions, furthe0072 studies are needed to fully understand the biology of stem cells and carefully assess their putative oncogenic properties. Moreover, the research on stem cells arouses fervent ethical, social and political debate. The Italian Society of Gastroenterology sponsored a workshop on stem cells held in Verona during the XVI Congress of the Federation of Italian Societies of Digestive Diseases (March 6-9, 2010). Here, we report on the issues discussed, including liver and intestinal diseases that may benefit from stem cell therapy, the biology of hepatic and intestinal tissue repair, and stem cell usage in clinical trials.
AB - Adult stem cells represent the self-renewing progenitors of numerous body tissues, and they are currently classified according to their origin and differentiation ability. In recent years, the research on stem cells has expanded enormously and holds therapeutic promises for many patients suffering from currently disabling diseases. This paper focuses on the possible use of stem cells in the two main clinical settings in gastroenterology, i.e., hepatic and intestinal diseases, which have a strong impact on public health worldwide. Despite encouraging results obtained in both regenerative medicine and immune-mediated conditions, furthe0072 studies are needed to fully understand the biology of stem cells and carefully assess their putative oncogenic properties. Moreover, the research on stem cells arouses fervent ethical, social and political debate. The Italian Society of Gastroenterology sponsored a workshop on stem cells held in Verona during the XVI Congress of the Federation of Italian Societies of Digestive Diseases (March 6-9, 2010). Here, we report on the issues discussed, including liver and intestinal diseases that may benefit from stem cell therapy, the biology of hepatic and intestinal tissue repair, and stem cell usage in clinical trials.
KW - Cell therapy
KW - Inflammatory bowel disease
KW - Liver disease
KW - Regenerative me-dicine
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=80054829135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054829135&partnerID=8YFLogxK
U2 - 10.3748/wjg.v17.i34.3870
DO - 10.3748/wjg.v17.i34.3870
M3 - Article
C2 - 22025875
AN - SCOPUS:80054829135
VL - 17
SP - 3870
EP - 3880
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 34
ER -