Therapeutic application of stem cells in gastroenterology: An up-date

Patrizia Burra, Debora Bizzaro, Rachele Ciccocioppo, Fabio Marra, Anna Chiara Piscaglia, Laura Porretti, Antonio Gasbarrini, Francesco Paolo Russo

Research output: Contribution to journalArticle

Abstract

Adult stem cells represent the self-renewing progenitors of numerous body tissues, and they are currently classified according to their origin and differentiation ability. In recent years, the research on stem cells has expanded enormously and holds therapeutic promises for many patients suffering from currently disabling diseases. This paper focuses on the possible use of stem cells in the two main clinical settings in gastroenterology, i.e., hepatic and intestinal diseases, which have a strong impact on public health worldwide. Despite encouraging results obtained in both regenerative medicine and immune-mediated conditions, furthe0072 studies are needed to fully understand the biology of stem cells and carefully assess their putative oncogenic properties. Moreover, the research on stem cells arouses fervent ethical, social and political debate. The Italian Society of Gastroenterology sponsored a workshop on stem cells held in Verona during the XVI Congress of the Federation of Italian Societies of Digestive Diseases (March 6-9, 2010). Here, we report on the issues discussed, including liver and intestinal diseases that may benefit from stem cell therapy, the biology of hepatic and intestinal tissue repair, and stem cell usage in clinical trials.

Original languageEnglish
Pages (from-to)3870-3880
Number of pages11
JournalWorld Journal of Gastroenterology
Volume17
Issue number34
DOIs
Publication statusPublished - Sep 14 2011

Fingerprint

Gastroenterology
Stem Cells
Stem Cell Research
Intestinal Diseases
Therapeutics
Adult Stem Cells
Regenerative Medicine
Liver
Cell- and Tissue-Based Therapy
Cell Biology
Liver Diseases
Public Health
Clinical Trials
Education

Keywords

  • Cell therapy
  • Inflammatory bowel disease
  • Liver disease
  • Regenerative me-dicine
  • Stem cells

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Burra, P., Bizzaro, D., Ciccocioppo, R., Marra, F., Piscaglia, A. C., Porretti, L., ... Russo, F. P. (2011). Therapeutic application of stem cells in gastroenterology: An up-date. World Journal of Gastroenterology, 17(34), 3870-3880. https://doi.org/10.3748/wjg.v17.i34.3870

Therapeutic application of stem cells in gastroenterology : An up-date. / Burra, Patrizia; Bizzaro, Debora; Ciccocioppo, Rachele; Marra, Fabio; Piscaglia, Anna Chiara; Porretti, Laura; Gasbarrini, Antonio; Russo, Francesco Paolo.

In: World Journal of Gastroenterology, Vol. 17, No. 34, 14.09.2011, p. 3870-3880.

Research output: Contribution to journalArticle

Burra, P, Bizzaro, D, Ciccocioppo, R, Marra, F, Piscaglia, AC, Porretti, L, Gasbarrini, A & Russo, FP 2011, 'Therapeutic application of stem cells in gastroenterology: An up-date', World Journal of Gastroenterology, vol. 17, no. 34, pp. 3870-3880. https://doi.org/10.3748/wjg.v17.i34.3870
Burra, Patrizia ; Bizzaro, Debora ; Ciccocioppo, Rachele ; Marra, Fabio ; Piscaglia, Anna Chiara ; Porretti, Laura ; Gasbarrini, Antonio ; Russo, Francesco Paolo. / Therapeutic application of stem cells in gastroenterology : An up-date. In: World Journal of Gastroenterology. 2011 ; Vol. 17, No. 34. pp. 3870-3880.
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