The therapeutic approach in the most common types of anemia is briefly reviewed. Therapy of sideropenic anemia is based on correction of the underlying cause of iron loss and replacement of body iron deposits. In megaloblastic anemia, it is useful to distinguish whether folate, vitamin B12, or combined folate and vitamin B12 deficiencies have led to anemia. Therapy is based on replacement. Anemia of chronic diseases can be improved by therapy with recombinant erythropoietin, commonly used in anemia from renal insufficiency. Therapy of warm autoimmune hemolytic anemias is based on corticosteroid therapy. Other therapeutic possibilities include splenectomy and immunosuppressive therapy. Cold autoimmune hemolytic anemias frequently only need cold avoidance. Therapy of thalassemic syndromes is based on red blood cells transfusions and iron chelation. Congenital red cell membrane defects need prophylaxis with folic acid. Splenectomy is frequently required in spherocytosis, less frequently in elliptocytosis. G6PD deficiency usually does not require any therapy, except during acute hemolytic crisis. PK deficiency usually requires folic acid prophylaxis, and splenectomy in selected cases. Iron chelation can be necessary.
|Translated title of the contribution||Therapeutic approach to anemia|
|Number of pages||8|
|Publication status||Published - 1999|
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