Therapeutic approaches for the treatment of renal disease in juvenile systemic lupus erythematosus: An international multicentre PRINTO study

Paivi M. Miettunen, Angela Pistorio, Elena Palmisani, Angelo Ravelli, Earl Silverman, Sheila Oliveira, Maria Alessio, Ruben Cuttica, Dimitrina Mihaylova, Graciela Espada, Srdjan Pasic, Antonella Insalaco, Seza Ozen, Oscar Porras, Flavio Sztajnbok, Dragana Lazarevic, Alberto Martini, Nicolino Ruperto

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To evaluate therapeutic approaches and response to therapy in juvenile systemic lupus erythematosus (SLE) with renal involvement in a large prospective international cohort from four geographic areas. Methods New onset and flared patients with active renal disease (proteinuria ≥0.5 g/24 h) were enrolled in 2001.2004. Therapeutic approaches and disease activity parameters were analysed at baseline, 6, 12 and 24 months. Response was assessed by the PRINTO/ACR criteria. Results: 218/557 (79.8% female subjects, 117 new onset and 101 flared) patients with active renal disease were identified; 66 patients were lost to follow-up and 11 died. Mean age at disease onset for new onset group was higher than for flared group (13.1 vs 10.2 years, p

Original languageEnglish
Pages (from-to)1503-1509
Number of pages7
JournalAnnals of the Rheumatic Diseases
Volume72
Issue number9
DOIs
Publication statusPublished - Sep 2013

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

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