Therapeutic approaches in vascular repair induced by adult bone marrow cells and circulating progenitor endothelial cells

Claudio Napoli, Antonio Balestrieri, Louis J. Ignarro

Research output: Contribution to journalArticlepeer-review

Abstract

Strong evidence indicates that bone marrow cells (BMCs) can contribute to the healing process of injured vascular system via CXCR4/Thymosin β4/Integrin α4β1/SDF-1 molecular pathways. We discuss the therapeutic approaches of BMCs and circulating endothelial progenitor cells (EPCs) to restore vascularization. Today some clinical trials employing BMCs in the treatment of peripheral vascular diseases have been completed with encouraging results. When large clinical controlled studies will be completed, the scientific community will evaluate this novel and promising therapeutic approach. Although some basic studies suggest the potential use of adult/somatic stem cell for vascular repair, other stringent data suggest that this potential is dependent also on growth factor synthesis rather than the formation of new arterial vessels. Considering the limitations of adult stem cells especially in elderly subjects, our point of view is that BMCs or exogenous BMC/EPC are candidate for adjunct cell-therapy applications in vascular repair.

Original languageEnglish
Pages (from-to)3245-3251
Number of pages7
JournalCurrent Pharmaceutical Design
Volume13
Issue number31
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Angiogenesis
  • Atherosclerosis
  • BMC
  • Bone marrow cell
  • Clinical trials
  • EPC
  • Hematopoietic stem cell
  • Oxidative stress
  • Peripheral vascular disease
  • Regenerative medicine
  • Vascular diseases

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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