Therapeutic benefits from nanoparticles: The potential significance of nanoscience in diseases with compromise to the blood brain barrier

Silke Krol, Richard Macrez, Fabian Docagne, Gilles Defer, Sophie Laurent, Masoud Rahman, Mohammad J. Hajipour, Patrick G. Kehoe, Morteza Mahmoudi

Research output: Contribution to journalArticlepeer-review

Abstract

Nanotechnology is an area of growing public interest. Its attractiveness stems from the promise offered socially and economically by the recent significant advances in nanotechnological development. Nanotechnology has already begun to be incorporated into the daily lives, but the level of its technological impact has yet to become clear. As a result, new properties never previously observed in these materials in either bulk form or as part of larger scale entities can be harnessed. Chemical processes can be tailored to a desired application, such as the enhancement of biocompatibility of implantable materials, for example. Due to their greater surface area per volume, nanomaterials can exhibit higher reactivity, increased capacity for mechanical strength, or magnetic or electrical properties. Targeted molecular imaging is important for a wide range of diagnostic purposes, such as the identification of inflammatory loci, the localization and staging of tumors, the visualization of vascular structures or specific disease states, and the examination of anatomy.

Original languageEnglish
Pages (from-to)1877-1903
Number of pages27
JournalChemical Reviews
Volume113
Issue number3
DOIs
Publication statusPublished - Mar 13 2013

ASJC Scopus subject areas

  • Chemistry(all)

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