Therapeutic drug monitoring is a feasible tool to personalize drug administration in neonates using new techniques: An overview on the pharmacokinetics and pharmacodynamics in neonatal age

Domenico Umberto De Rose, Sara Cairoli, Marco Dionisi, Alessandra Santisi, Luca Massenzi, Bianca Maria Goffredo, Carlo Dionisi-Vici, Andrea Dotta, Cinzia Auriti

Research output: Contribution to journalReview articlepeer-review

Abstract

Therapeutic drug monitoring (TDM) should be adopted in all neonatal intensive care units (NICUs), where the most preterm and fragile babies are hospitalized and treated with many drugs, considering that organs and metabolic pathways undergo deep and progressive maturation processes after birth. Different developmental changes are involved in interindividual variability in response to drugs. A crucial point of TDM is the choice of the bioanalytical method and of the sample to use. TDM in neonates is primarily used for antibiotics, antifungals, and antiepileptic drugs in clinical practice. TDM appears to be particularly promising in specific populations: neonates who undergo therapeutic hypothermia or extracorporeal life support, preterm infants, infants who need a tailored dose of anticancer drugs. This review provides an overview of the latest advances in this field, showing options for a personalized therapy in newborns and infants.

Original languageEnglish
Article number5898
Pages (from-to)1-25
Number of pages25
JournalInternational Journal of Molecular Sciences
Volume21
Issue number16
DOIs
Publication statusPublished - Aug 2 2020

Keywords

  • Drugs
  • Infants
  • Neonates
  • Newborns
  • Personalized medicine
  • Pharmacodynamics
  • Pharmacokinetics
  • Therapeutic drug monitoring

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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