Therapeutic drug monitoring of gentamicin in neonatal intensive care unit: experience in 68 newborns.

M. Testa, V. Fanos, V. Martinelli, M. Stronati, M. Mussap, M. Del Zompo

Research output: Contribution to journalArticle

Abstract

A proper dosing regimen is fundamental when antibiotics with a low therapeutic index, as aminoglycosides (AMG), are used. AMG pharmacokinetics present a strong interindividual and intraindividual variability in neonates; in the premature neonate AMG clearance is reduced and the half-life is longer, leading to higher serum trough concentrations. Neonates may require therapeutic drug monitoring (TDM) and a "tailored" therapeutic regimen. The aim of this work is to present our personal experience wtih TDM of gentamicin in 68 newborns and to compare it with data available in the literature.

Original languageEnglish
Pages (from-to)39-41
Number of pages3
JournalJournal of Chemotherapy
Volume19 Suppl 2
Publication statusPublished - Oct 2007

ASJC Scopus subject areas

  • Medicine(all)

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    Testa, M., Fanos, V., Martinelli, V., Stronati, M., Mussap, M., & Del Zompo, M. (2007). Therapeutic drug monitoring of gentamicin in neonatal intensive care unit: experience in 68 newborns. Journal of Chemotherapy, 19 Suppl 2, 39-41.