Therapeutic efficacy of intraperitoneal polymyxin B and polymyxin-like peptides alone or combined with levofloxacin in rat models of septic shock

Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Federico Mocchegiani, Alessandra Mataloni Paggi, Fiorenza Orlando, Wojciech Kamysz, Franciszek Kasprzykowski, Zbigniew Maćkiewicz, Giorgio Scalise, Vittorio Saba

Research output: Contribution to journalArticlepeer-review

Abstract

The efficacy of two polymyxin-like peptides, KFFKFFKFF and IKFLKFLKFL, alone and combined with levofloxacin, was investigated in a rat model of septic shock. Rats were given an ip injection of 2 × 1010 cfu of Escherichia coli and randomized to receive ip isotonic sodium chloride solution, 7 mg/kg levofloxacin, 1 mg/kg polymyxin B and 1 mg/kg of each polymyxin-like peptides alone or combined with 7 mg/kg levofloxacin. Polymyxins achieved a significant reduction in plasma endotoxin and tumour necrosis factor α (TNF-α) concentration. Levofloxacin significantly reduced the bacterial growth and TNF-α concentration. The combinations of polymyxin-like peptides and levofloxacin demonstrated the highest efficacy.

Original languageEnglish
Pages (from-to)193-196
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume49
Issue number1
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Microbiology
  • Pharmacology

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