Therapeutic impact of 18F-FDG PET/CT in recurrent differentiated thyroid carcinoma

Fabio Pomerri, Anna Rita Cervino, Faise Al Bunni, Laura Evangelista, Pier Carlo Muzzio

Research output: Contribution to journalArticle

Abstract

Purpose: 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) has proved effective in detecting recurrent or metastatic differentiated thyroid carcinoma (DTC) in the follow-up of operated DTC patients with high thyroglobulin (Tg) levels and negative findings on radioiodine whole-body scan. The aim of this retrospective study was to assess the impact of PET/CT on the planning of appropriate treatment for known recurrent disease in operated DTC patients. Materials and methods: The study concerned 44 consecutive DTC patients (36 papillary, 8 follicular), who underwent total thyroidectomy and thyroid remnant ablation with 131I and PET/CT. All patients had proven or strongly suspected recurrent disease judging from neck ultrasound (US) and fine-needle aspiration cytology, and detectable basal Tg levels. Results: PET/CT findings were positive in 25/44 patients (56.81 %) and negative in 19. A positive PET/CT result predicted resectable tumour recurrences in 19/25 patients, but also detected additional tumour sites that prompted changes to the treatment plan in 6/25 patients (24 %). A negative PET/CT result led to clinical monitoring for 11/19 patients (57.89 %). Conclusions: PET/CT can help select patients, who might benefit from a tailored therapy by improving the detection of local recurrences not apparent on neck US or metastases.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalRadiologia Medica
Volume119
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Positron emission tomography/computed tomography
  • Thyroglobulin
  • Thyroid carcinoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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