Therapeutic imprinting of the immune system: Towards a remission of AIDS in primates?

Andrea Savarino, Enrico Garaci

Research output: Contribution to journalArticle

Abstract

Our inability to cure HIV/AIDS is related to the ability of the virus to establish reservoirs during treatment. In order to develop new strategies, it is certainly essential that a suitable animal model be implemented. In the recent work of Shytaj et al., it has been possible to inhibit viral replication to levels below the assay detection limit in the macaque AIDS model. Moreover, different therapeutic regimens applied to the rhesus macaque AIDS model (herein reviewed), including ours, are starting to show the potential to induce, following therapy suspension, conditions reminiscent of a drug-free control of the infection.

Original languageEnglish
Article number75
JournalRetrovirology
Volume9
DOIs
Publication statusPublished - Sep 14 2012

Keywords

  • Anti-reservoir
  • Antiretroviral therapy
  • Auranofin
  • Buthionine sulfoximine (BSO)
  • Central memory CD4+ T-cells
  • Functional cure
  • Macaque AIDS model
  • Maraviroc

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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