Abstract
BACKGROUND: Neck dissection is considered the treatment of choice in patients with lateral neck metastases from well-differentiated thyroid cancer.
METHODS: A multicenter, retrospective review of patients who underwent therapeutic lateral neck dissection for well-differentiated thyroid carcinoma was carried out.
RESULTS: The study included a total of 405 lateral neck dissections performed in 352 patients; 197 women (56%) and 155 men (44%). When considering ipsilateral neck metastases, levels IIa, IIb, III, IV, Va, Vb, and V (not otherwise specified) were involved in 42%, 6%, 73%, 67%, 11%, 31%, and 35% of cases, respectively. Five-year and 10-year overall survival (OS) were 93% and 81%, respectively. Age >55 years, pathologic T (pT)4 category, tumor diameter >4 cm, aggressive variants of well-differentiated thyroid carcinoma, endovascular invasion, and number of positive nodes >5 turned out to be the most important prognostic factors.
CONCLUSION: Neck dissection is a valid treatment option in the presence of neck metastasis from well-differentiated thyroid carcinoma. Levels IIa, III, IV, and Vb should always be removed.
| Original language | English |
|---|---|
| Journal | Head and Neck Surgery |
| Volume | 40 |
| Issue number | 2 |
| DOIs | |
| Publication status | E-pub ahead of print - Sep 30 2017 |
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Keywords
- Journal Article
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Therapeutic lateral neck dissection in well-differentiated thyroid cancer : Analysis on factors predicting distribution of positive nodes and prognosis. / Lombardi, Davide; Paderno, Alberto; Giordano, Davide; Barbieri, Diego; Taboni, Stefano; Piazza, Cesare; Cappelli, Carlo; Bertagna, Francesco; Barbieri, Verter; Piana, Simonetta; Bellafiore, Salvatore; Spriano, Giuseppe; Mercante, Giuseppe; Nicolai, Piero.
In: Head and Neck Surgery, Vol. 40, No. 2, 30.09.2017.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Therapeutic lateral neck dissection in well-differentiated thyroid cancer
T2 - Analysis on factors predicting distribution of positive nodes and prognosis
AU - Lombardi, Davide
AU - Paderno, Alberto
AU - Giordano, Davide
AU - Barbieri, Diego
AU - Taboni, Stefano
AU - Piazza, Cesare
AU - Cappelli, Carlo
AU - Bertagna, Francesco
AU - Barbieri, Verter
AU - Piana, Simonetta
AU - Bellafiore, Salvatore
AU - Spriano, Giuseppe
AU - Mercante, Giuseppe
AU - Nicolai, Piero
N1 - © 2017 Wiley Periodicals, Inc.
PY - 2017/9/30
Y1 - 2017/9/30
N2 - BACKGROUND: Neck dissection is considered the treatment of choice in patients with lateral neck metastases from well-differentiated thyroid cancer.METHODS: A multicenter, retrospective review of patients who underwent therapeutic lateral neck dissection for well-differentiated thyroid carcinoma was carried out.RESULTS: The study included a total of 405 lateral neck dissections performed in 352 patients; 197 women (56%) and 155 men (44%). When considering ipsilateral neck metastases, levels IIa, IIb, III, IV, Va, Vb, and V (not otherwise specified) were involved in 42%, 6%, 73%, 67%, 11%, 31%, and 35% of cases, respectively. Five-year and 10-year overall survival (OS) were 93% and 81%, respectively. Age >55 years, pathologic T (pT)4 category, tumor diameter >4 cm, aggressive variants of well-differentiated thyroid carcinoma, endovascular invasion, and number of positive nodes >5 turned out to be the most important prognostic factors.CONCLUSION: Neck dissection is a valid treatment option in the presence of neck metastasis from well-differentiated thyroid carcinoma. Levels IIa, III, IV, and Vb should always be removed.
AB - BACKGROUND: Neck dissection is considered the treatment of choice in patients with lateral neck metastases from well-differentiated thyroid cancer.METHODS: A multicenter, retrospective review of patients who underwent therapeutic lateral neck dissection for well-differentiated thyroid carcinoma was carried out.RESULTS: The study included a total of 405 lateral neck dissections performed in 352 patients; 197 women (56%) and 155 men (44%). When considering ipsilateral neck metastases, levels IIa, IIb, III, IV, Va, Vb, and V (not otherwise specified) were involved in 42%, 6%, 73%, 67%, 11%, 31%, and 35% of cases, respectively. Five-year and 10-year overall survival (OS) were 93% and 81%, respectively. Age >55 years, pathologic T (pT)4 category, tumor diameter >4 cm, aggressive variants of well-differentiated thyroid carcinoma, endovascular invasion, and number of positive nodes >5 turned out to be the most important prognostic factors.CONCLUSION: Neck dissection is a valid treatment option in the presence of neck metastasis from well-differentiated thyroid carcinoma. Levels IIa, III, IV, and Vb should always be removed.
KW - Journal Article
U2 - 10.1002/hed.24936
DO - 10.1002/hed.24936
M3 - Article
C2 - 28963802
VL - 40
JO - Head and Neck Surgery
JF - Head and Neck Surgery
SN - 1043-3074
IS - 2
ER -