Therapeutic lateral neck dissection in well-differentiated thyroid cancer: Analysis on factors predicting distribution of positive nodes and prognosis

D. Lombardi; A. Paderno; D. Giordano; D. Barbieri; S. Taboni; C. Piazza; C. Cappelli; F. Bertagna; V. Barbieri; S. Piana; S. Bellafiore; G. Spriano; G. Mercante; P. Nicolai

doi:10.1002/hed.24936 [doi]

Therapeutic lateral neck dissection in well-differentiated thyroid cancer: Analysis on factors predicting distribution of positive nodes and prognosis

D. Lombardi, A. Paderno, D. Giordano, D. Barbieri, S. Taboni, C. Piazza, C. Cappelli, F. Bertagna, V. Barbieri, S. Piana, S. Bellafiore, G. Spriano, G. Mercante, P. Nicolai

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Neck dissection is considered the treatment of choice in patients with lateral neck metastases from well-differentiated thyroid cancer. METHODS: A multicenter, retrospective review of patients who underwent therapeutic lateral neck dissection for well-differentiated thyroid carcinoma was carried out. RESULTS: The study included a total of 405 lateral neck dissections performed in 352 patients; 197 women (56%) and 155 men (44%). When considering ipsilateral neck metastases, levels IIa, IIb, III, IV, Va, Vb, and V (not otherwise specified) were involved in 42%, 6%, 73%, 67%, 11%, 31%, and 35% of cases, respectively. Five-year and 10-year overall survival (OS) were 93% and 81%, respectively. Age >55 years, pathologic T (pT)4 category, tumor diameter >4 cm, aggressive variants of well-differentiated thyroid carcinoma, endovascular invasion, and number of positive nodes >5 turned out to be the most important prognostic factors. CONCLUSION: Neck dissection is a valid treatment option in the presence of neck metastasis from well-differentiated thyroid carcinoma. Levels IIa, III, IV, and Vb should always be removed.

Original language	English
Journal	Head and Neck Surgery
DOIs	https://doi.org/10.1002/hed.24936 [doi]
Publication status	Published - Feb 2018

Keywords

lateral neck metastases
neck dissection
neck levels
survival
well-differentiated thyroid cancer

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Lombardi, D., Paderno, A., Giordano, D., Barbieri, D., Taboni, S., Piazza, C., Cappelli, C., Bertagna, F., Barbieri, V., Piana, S., Bellafiore, S., Spriano, G., Mercante, G., & Nicolai, P. (2018). Therapeutic lateral neck dissection in well-differentiated thyroid cancer: Analysis on factors predicting distribution of positive nodes and prognosis. Head and Neck Surgery. https://doi.org/10.1002/hed.24936 [doi]

Therapeutic lateral neck dissection in well-differentiated thyroid cancer: Analysis on factors predicting distribution of positive nodes and prognosis. / Lombardi, D.; Paderno, A.; Giordano, D.; Barbieri, D.; Taboni, S.; Piazza, C.; Cappelli, C.; Bertagna, F.; Barbieri, V.; Piana, S.; Bellafiore, S.; Spriano, G.; Mercante, G.; Nicolai, P.

In: Head and Neck Surgery, 02.2018.

Research output: Contribution to journal › Article › peer-review

Lombardi, D, Paderno, A, Giordano, D, Barbieri, D, Taboni, S, Piazza, C, Cappelli, C, Bertagna, F, Barbieri, V, Piana, S, Bellafiore, S, Spriano, G , Mercante, G & Nicolai, P 2018, 'Therapeutic lateral neck dissection in well-differentiated thyroid cancer: Analysis on factors predicting distribution of positive nodes and prognosis', Head and Neck Surgery. https://doi.org/10.1002/hed.24936 [doi]

Lombardi, D. ; Paderno, A. ; Giordano, D. ; Barbieri, D. ; Taboni, S. ; Piazza, C. ; Cappelli, C. ; Bertagna, F. ; Barbieri, V. ; Piana, S. ; Bellafiore, S. ; Spriano, G. ; Mercante, G. ; Nicolai, P. / Therapeutic lateral neck dissection in well-differentiated thyroid cancer: Analysis on factors predicting distribution of positive nodes and prognosis. In: Head and Neck Surgery. 2018.

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abstract = "BACKGROUND: Neck dissection is considered the treatment of choice in patients with lateral neck metastases from well-differentiated thyroid cancer. METHODS: A multicenter, retrospective review of patients who underwent therapeutic lateral neck dissection for well-differentiated thyroid carcinoma was carried out. RESULTS: The study included a total of 405 lateral neck dissections performed in 352 patients; 197 women (56%) and 155 men (44%). When considering ipsilateral neck metastases, levels IIa, IIb, III, IV, Va, Vb, and V (not otherwise specified) were involved in 42%, 6%, 73%, 67%, 11%, 31%, and 35% of cases, respectively. Five-year and 10-year overall survival (OS) were 93% and 81%, respectively. Age >55 years, pathologic T (pT)4 category, tumor diameter >4 cm, aggressive variants of well-differentiated thyroid carcinoma, endovascular invasion, and number of positive nodes >5 turned out to be the most important prognostic factors. CONCLUSION: Neck dissection is a valid treatment option in the presence of neck metastasis from well-differentiated thyroid carcinoma. Levels IIa, III, IV, and Vb should always be removed.",

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author = "D. Lombardi and A. Paderno and D. Giordano and D. Barbieri and S. Taboni and C. Piazza and C. Cappelli and F. Bertagna and V. Barbieri and S. Piana and S. Bellafiore and G. Spriano and G. Mercante and P. Nicolai",

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T1 - Therapeutic lateral neck dissection in well-differentiated thyroid cancer: Analysis on factors predicting distribution of positive nodes and prognosis

AU - Lombardi, D.

AU - Paderno, A.

AU - Giordano, D.

AU - Barbieri, D.

AU - Taboni, S.

AU - Piazza, C.

AU - Cappelli, C.

AU - Bertagna, F.

AU - Barbieri, V.

AU - Piana, S.

AU - Bellafiore, S.

AU - Spriano, G.

AU - Mercante, G.

AU - Nicolai, P.

PY - 2018/2

Y1 - 2018/2

N2 - BACKGROUND: Neck dissection is considered the treatment of choice in patients with lateral neck metastases from well-differentiated thyroid cancer. METHODS: A multicenter, retrospective review of patients who underwent therapeutic lateral neck dissection for well-differentiated thyroid carcinoma was carried out. RESULTS: The study included a total of 405 lateral neck dissections performed in 352 patients; 197 women (56%) and 155 men (44%). When considering ipsilateral neck metastases, levels IIa, IIb, III, IV, Va, Vb, and V (not otherwise specified) were involved in 42%, 6%, 73%, 67%, 11%, 31%, and 35% of cases, respectively. Five-year and 10-year overall survival (OS) were 93% and 81%, respectively. Age >55 years, pathologic T (pT)4 category, tumor diameter >4 cm, aggressive variants of well-differentiated thyroid carcinoma, endovascular invasion, and number of positive nodes >5 turned out to be the most important prognostic factors. CONCLUSION: Neck dissection is a valid treatment option in the presence of neck metastasis from well-differentiated thyroid carcinoma. Levels IIa, III, IV, and Vb should always be removed.

AB - BACKGROUND: Neck dissection is considered the treatment of choice in patients with lateral neck metastases from well-differentiated thyroid cancer. METHODS: A multicenter, retrospective review of patients who underwent therapeutic lateral neck dissection for well-differentiated thyroid carcinoma was carried out. RESULTS: The study included a total of 405 lateral neck dissections performed in 352 patients; 197 women (56%) and 155 men (44%). When considering ipsilateral neck metastases, levels IIa, IIb, III, IV, Va, Vb, and V (not otherwise specified) were involved in 42%, 6%, 73%, 67%, 11%, 31%, and 35% of cases, respectively. Five-year and 10-year overall survival (OS) were 93% and 81%, respectively. Age >55 years, pathologic T (pT)4 category, tumor diameter >4 cm, aggressive variants of well-differentiated thyroid carcinoma, endovascular invasion, and number of positive nodes >5 turned out to be the most important prognostic factors. CONCLUSION: Neck dissection is a valid treatment option in the presence of neck metastasis from well-differentiated thyroid carcinoma. Levels IIa, III, IV, and Vb should always be removed.

KW - lateral neck metastases

KW - neck dissection

KW - neck levels

KW - survival

KW - well-differentiated thyroid cancer

U2 - 10.1002/hed.24936 [doi]

DO - 10.1002/hed.24936 [doi]

M3 - Article

JO - Head and Neck Surgery

JF - Head and Neck Surgery

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