Therapeutic management of chronic hepatitis B in clinical practice: A region-wide survey

Edoardo G. Giannini, Simona Marenco, Silvia Boni, Andrea Beltrame, Laura A. Nicolini, Lucia Taramasso, Marcello Feasi, Alessandro Grasso, Pasqualina De Leo, Gianfranco Percario, Valentina Bartolacci, Stefania Artioli, Claudio Viscoli, Giovanni Cassola, Roberto Testa, Marco Anselmo, Giovanni Riccio, Vincenzo Savarino, Antonino Picciotto

Research output: Contribution to journalArticlepeer-review


GOALS:: To characterize the clinical and treatment pattern in a large population of hepatitis B virus (HBV) patients managed at tertiary referral centers in clinical practice. BACKGROUND:: Successful treatment, either with interferon (IFN) or nucleos(t)ide analogs (NUCs), of chronic HBV infection is associated with improved long-term patient outcome. However, in clinical practice, the actual management of these patients is not well characterized, and data regarding treatment pattern in this setting are lacking. METHODS:: In this cross-sectional study, we evaluated 505 patients chronically infected with HBV alone and who had at least 1-year follow-up. We assessed indication to, rate of, and type of treatment as well as the characteristics of treated patients. RESULTS:: Overall prevalence of positivity for HBe antigen was 19.3%, and the majority of patients had chronic hepatitis (47.5%). Non-Italian patients represented approximately one third of the population (27.1%). Among patients with indication to antiviral therapy (n=318), treatment was actually carried out in 264 patients (83.0%), prevalently with NUCs (65.9%). IFN-treated patients were younger (P

Original languageEnglish
Pages (from-to)228-234
Number of pages7
JournalJournal of Clinical Gastroenterology
Issue number3
Publication statusPublished - Mar 13 2015


  • Antiviral therapy
  • Chronic hepatitis
  • Cirrhosis
  • Hepatocellular carcinoma
  • Interferon
  • Nucleotide analogs
  • Outcome

ASJC Scopus subject areas

  • Gastroenterology


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