TY - JOUR
T1 - Therapeutic management of chronic hepatitis B in clinical practice
T2 - A region-wide survey
AU - Giannini, Edoardo G.
AU - Marenco, Simona
AU - Boni, Silvia
AU - Beltrame, Andrea
AU - Nicolini, Laura A.
AU - Taramasso, Lucia
AU - Feasi, Marcello
AU - Grasso, Alessandro
AU - De Leo, Pasqualina
AU - Percario, Gianfranco
AU - Bartolacci, Valentina
AU - Artioli, Stefania
AU - Viscoli, Claudio
AU - Cassola, Giovanni
AU - Testa, Roberto
AU - Anselmo, Marco
AU - Riccio, Giovanni
AU - Savarino, Vincenzo
AU - Picciotto, Antonino
PY - 2015/3/13
Y1 - 2015/3/13
N2 - GOALS:: To characterize the clinical and treatment pattern in a large population of hepatitis B virus (HBV) patients managed at tertiary referral centers in clinical practice. BACKGROUND:: Successful treatment, either with interferon (IFN) or nucleos(t)ide analogs (NUCs), of chronic HBV infection is associated with improved long-term patient outcome. However, in clinical practice, the actual management of these patients is not well characterized, and data regarding treatment pattern in this setting are lacking. METHODS:: In this cross-sectional study, we evaluated 505 patients chronically infected with HBV alone and who had at least 1-year follow-up. We assessed indication to, rate of, and type of treatment as well as the characteristics of treated patients. RESULTS:: Overall prevalence of positivity for HBe antigen was 19.3%, and the majority of patients had chronic hepatitis (47.5%). Non-Italian patients represented approximately one third of the population (27.1%). Among patients with indication to antiviral therapy (n=318), treatment was actually carried out in 264 patients (83.0%), prevalently with NUCs (65.9%). IFN-treated patients were younger (P
AB - GOALS:: To characterize the clinical and treatment pattern in a large population of hepatitis B virus (HBV) patients managed at tertiary referral centers in clinical practice. BACKGROUND:: Successful treatment, either with interferon (IFN) or nucleos(t)ide analogs (NUCs), of chronic HBV infection is associated with improved long-term patient outcome. However, in clinical practice, the actual management of these patients is not well characterized, and data regarding treatment pattern in this setting are lacking. METHODS:: In this cross-sectional study, we evaluated 505 patients chronically infected with HBV alone and who had at least 1-year follow-up. We assessed indication to, rate of, and type of treatment as well as the characteristics of treated patients. RESULTS:: Overall prevalence of positivity for HBe antigen was 19.3%, and the majority of patients had chronic hepatitis (47.5%). Non-Italian patients represented approximately one third of the population (27.1%). Among patients with indication to antiviral therapy (n=318), treatment was actually carried out in 264 patients (83.0%), prevalently with NUCs (65.9%). IFN-treated patients were younger (P
KW - Antiviral therapy
KW - Chronic hepatitis
KW - Cirrhosis
KW - Hepatocellular carcinoma
KW - Interferon
KW - Nucleotide analogs
KW - Outcome
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U2 - 10.1097/MCG.0000000000000106
DO - 10.1097/MCG.0000000000000106
M3 - Article
C2 - 24583753
AN - SCOPUS:84922703422
VL - 49
SP - 228
EP - 234
JO - Journal of Clinical Gastroenterology
JF - Journal of Clinical Gastroenterology
SN - 0192-0790
IS - 3
ER -