Therapeutic monitoring of antiepileptic drugs. II--Analytical techniques.

F. Albani, R. Riva, A. Baruzzi

Research output: Contribution to journalArticlepeer-review


Recent development of analytical techniques for therapeutic drug monitoring of antiepileptic drugs are reviewed. The most commonly used procedures are high performance liquid chromatography (HPLC) and immunochemical techniques. Innovations in HPLC include commercialization of instrumentations for automatic extraction and injection of biological samples and development of restricted access media columns for direct injection of plasma without prior extraction. For immunochemical techniques, principles of "classical" major procedures are described together with the new immunoenzymatic and immunochromatographic methods in solid phase, specifically developed with the aim of making drug monitoring possible outside the traditional laboratory.

Original languageEnglish
Pages (from-to)671-680
Number of pages10
Issue number5 Suppl
Publication statusPublished - May 1992

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science


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