Therapeutic options following pneumonectomy in non-small cell lung cancer

Research output: Contribution to journalReview articlepeer-review


ABSTRACT: Introduction: Pneumonectomy can be considered the most appropriate treatment for lung cancer that cannot be removed by lesser resection on. Areas covered: Therapeutic options following pneumonectomy may be required at least in 3 different scenarios: 1) an early approach due to acute surgical complications 2) a late approach due to chronic surgical complications 3) an integrated radio-chemotherapeutic adjuvant approach for advanced stages. In this review we focused on these three settings with particular emphasis to surgical approach as well as to alternative options. Expert commentary: Pneumonectomy itself does not preclude postoperative additional treatments, if needed, to maximize oncological results and to manage potential short or long term complications. However, as pneumonectomy puts a significant physiological stress on the respiratory and circulatory systems, the benefits and risks of pneumonectomy should be compared with those of alternative, non-resectional treatment modalities.

Original languageEnglish
Pages (from-to)919-925
Number of pages7
JournalExpert Review of Respiratory Medicine
Issue number8
Publication statusPublished - Aug 2 2016


  • adjuvant chemotherapy
  • Pneumonectomy
  • radiotherapy
  • single-lung surgery
  • thermal ablation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health


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