Therapeutic Options for Infections due to vanB Genotype Vancomycin-Resistant Enterococci

N. Riccardi, J. Monticelli, R. M. Antonello, G. Di Lallo, D. Frezza, R. Luzzati, S. Di Bella

Research output: Contribution to journalArticlepeer-review

Abstract

Enterococci are ubiquitous, facultative, anaerobic Gram-positive bacteria that mainly reside, as part of the normal microbiota, in the gastrointestinal tracts of several animal species, including humans. These bacteria have the capability to turn from a normal gut commensal organism to an invasive pathogen in patients debilitated by prolonged hospitalization, concurrent illnesses, and/or exposed to broad-spectrum antibiotics. The majority of vancomycin-resistant enterococcus (VRE) infections are linked to the vanA genotype; however, outbreaks caused by vanB-type VREs have been increasingly reported, representing a new challenge for effective antimicrobial treatment. Teicoplanin, daptomycin, fosfomycin, and linezolid are useful antimicrobials for infections due to vanB enterococci. In addition, new drugs have been developed (AN - 32799629
Original languageEnglish
JournalMicrobial Drug Resistance
DOIs
Publication statusPublished - Aug 14 2020

Keywords

  • VRE antibiotics infections

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