Therapeutic potential of new antiinflammatory drugs

Annamaria Vezzani, Tamas Bartfai, Marco Bianchi, Carlo Rossetti, Jacqueline French

Research output: Contribution to journalArticle

Abstract

Experimental and clinical findings have shown in the past decade that specific proinflammatory mediators and their cognate receptors are upregulated in epileptic brain tissue. In particular, the IL-1 receptor (R)/Toll-like receptor (TLR) signaling pathways are activated in experimental models of seizures and in human epileptic tissue from drug-resistant patients. Pharmacological targeting of these proinflammatory pathways using selective receptor antagonists, or the use of transgenic mice with perturbed cell signaling, demostrated that the activation of IL-1R type 1 and TLR4 by their respective endogenous ligands, i.e., interleukin (IL)-1b and High Mobility Group Box 1, is implicated in the precipitation and recurrence of experimentally induced seizures in rodents. This evidence highlights a new target system for pharmacological intervention to inhibit seizures by interfering with mechanisms involved in their genesis and recurrence.

Original languageEnglish
Pages (from-to)67-69
Number of pages3
JournalEpilepsia
Volume52
Issue numberSUPPL. 8
DOIs
Publication statusPublished - Oct 2011

Keywords

  • ICE/Caspase-1
  • IL-1β
  • Interleukin-1 receptor/Toll-like receptor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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