Therapeutic potential of new antiinflammatory drugs

Annamaria Vezzani, Tamas Bartfai, Marco Bianchi, Carlo Rossetti, Jacqueline French

Research output: Contribution to journalArticlepeer-review

Abstract

Experimental and clinical findings have shown in the past decade that specific proinflammatory mediators and their cognate receptors are upregulated in epileptic brain tissue. In particular, the IL-1 receptor (R)/Toll-like receptor (TLR) signaling pathways are activated in experimental models of seizures and in human epileptic tissue from drug-resistant patients. Pharmacological targeting of these proinflammatory pathways using selective receptor antagonists, or the use of transgenic mice with perturbed cell signaling, demostrated that the activation of IL-1R type 1 and TLR4 by their respective endogenous ligands, i.e., interleukin (IL)-1b and High Mobility Group Box 1, is implicated in the precipitation and recurrence of experimentally induced seizures in rodents. This evidence highlights a new target system for pharmacological intervention to inhibit seizures by interfering with mechanisms involved in their genesis and recurrence.

Original languageEnglish
Pages (from-to)67-69
Number of pages3
JournalEpilepsia
Volume52
Issue numberSUPPL. 8
DOIs
Publication statusPublished - Oct 2011

Keywords

  • ICE/Caspase-1
  • IL-1β
  • Interleukin-1 receptor/Toll-like receptor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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