Therapeutic potential of TGF-β inhibition in chronic renal failure

Elena Gagliardini; Ariela Benigni

doi:10.1517/14712598.7.3.293

Therapeutic potential of TGF-β inhibition in chronic renal failure

Elena Gagliardini, Ariela Benigni

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article

Abstract

Chronic kidney diseases are emerging as a worldwide public health problem. The progression of kidney diseases closely correlates with the accumulation of extracellular matrix leading to glomerulosclerosis and tubulointerstitial injury. Transforming growth factor (TGF)-β has been identified as a key mediator of kidney matrix accumulation. Overexpression of TGF-β isoforms and their receptors was observed in a variety of renal diseases in both animals and humans. Given its crucial role in fibrotic kidney disease, TGF-β has been recently considered as a possible target in the management of chronic renal diseases. This review discusses the role of TGF-β in renal fibrosis and provides an overview of the strategies that, when interfering with TGF-β expression and signalling, could be employed as new renoprotective treatments.

Original language	English
Pages (from-to)	293-304
Number of pages	12
Journal	Expert Opinion on Biological Therapy
Volume	7
Issue number	3
DOIs	https://doi.org/10.1517/14712598.7.3.293
Publication status	Published - Mar 2007

Keywords

Progressive nephropathies
Proteinuria
Renal fibrosis
Transforming growth factor-β

ASJC Scopus subject areas

Pharmacology
Biochemistry, Genetics and Molecular Biology(all)
Genetics
Immunology

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Gagliardini, E., & Benigni, A. (2007). Therapeutic potential of TGF-β inhibition in chronic renal failure. Expert Opinion on Biological Therapy, 7(3), 293-304. https://doi.org/10.1517/14712598.7.3.293

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