Abstract
Chronic kidney diseases are emerging as a worldwide public health problem. The progression of kidney diseases closely correlates with the accumulation of extracellular matrix leading to glomerulosclerosis and tubulointerstitial injury. Transforming growth factor (TGF)-β has been identified as a key mediator of kidney matrix accumulation. Overexpression of TGF-β isoforms and their receptors was observed in a variety of renal diseases in both animals and humans. Given its crucial role in fibrotic kidney disease, TGF-β has been recently considered as a possible target in the management of chronic renal diseases. This review discusses the role of TGF-β in renal fibrosis and provides an overview of the strategies that, when interfering with TGF-β expression and signalling, could be employed as new renoprotective treatments.
| Original language | English |
|---|---|
| Pages (from-to) | 293-304 |
| Number of pages | 12 |
| Journal | Expert Opinion on Biological Therapy |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2007 |
Keywords
- Progressive nephropathies
- Proteinuria
- Renal fibrosis
- Transforming growth factor-β
ASJC Scopus subject areas
- Pharmacology
- Biochemistry, Genetics and Molecular Biology(all)
- Genetics
- Immunology