Therapeutic targeting of the bone pre-metastatic niche

Ester Simeone, Antonio Maria Grimaldi, Paolo Antonio Ascierto, Francesco Merolla, Gennaro Ilardi, Maria Siano, Stefania Staibano

Research output: Chapter in Book/Report/Conference proceedingChapter


Most of relevant strategies designed for therapeutic targeting the highly lethal, bone-metastasizing and AR-resistant prostate cancers, have been reported and discussed elsewhere in this book. In this chapter, we aim to provide an overview of the rationale underlying the proposal of most of promising new therapeutic alternatives, most of which are still the early phase of evaluation. Once more, we strongly wish to outline that the deeper understanding of the intricate crosstalks between the manifold molecular pathways responsible for the gain of invasive and metastasizing abilities of tumor cells, is giving rise to a previously unthinkable picture of the complex prostate cancer biology. A new, fascinating therapeutic era is opening up for the treatment of advanced prostate cancers.

Original languageEnglish
Title of host publicationProstate Cancer: Shifting from Morphology to Biology
PublisherSpringer Netherlands
Number of pages8
ISBN (Print)9789400771499, 9400771487, 9789400771482
Publication statusPublished - Jul 1 2013

ASJC Scopus subject areas

  • Medicine(all)


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