Therapy of chronic hepatitis C with leukocyte interferon-α

F. Toccaceli, V. Russo, S. Rosati, F. Iacomi, A. Monini, A. Canneti, F. Passarelli, V. Laghi

Research output: Contribution to journalArticle

Abstract

Objectives. To evaluate biochemical, virologic and histologic effects of leukocyte IFN-α in chronic hepatitis C. Cases. 61 patients with chronic hepatitis C treated with 3 or 6 MU of IFN-α thrice a week for 12 or 24 months. Results. A complete biochemical response was observed in 50% of the patients after 6 months of treatment and in 58% after 12 months. Sustained responses were found, 3 and 6 months after the end of therapy, in 71% and 53% respectively of complete responders. Patients with undetectable pretreatment serum HCV-RNA showed, after 6 and 12 months of therapy, a higher complete response rate (57% and 75%, respectively) than patients with a positive HCV-RNA test (42% and 50%). Among patients with a high (≥10) pretreatment Knodell histologic activity index, after 6 months of therapy non-responders were more frequent (60%) than among patients with low (

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalMediterranean Journal of Infectious and Parasitic Diseases
Volume11
Issue number1
Publication statusPublished - 1996

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Chronic Hepatitis C
Interferon-alpha
Therapeutics
RNA
Leukocytes
Serum

Keywords

  • chronic hepatitis
  • HCV
  • leukocyte interferon

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Therapy of chronic hepatitis C with leukocyte interferon-α. / Toccaceli, F.; Russo, V.; Rosati, S.; Iacomi, F.; Monini, A.; Canneti, A.; Passarelli, F.; Laghi, V.

In: Mediterranean Journal of Infectious and Parasitic Diseases, Vol. 11, No. 1, 1996, p. 33-39.

Research output: Contribution to journalArticle

Toccaceli, F, Russo, V, Rosati, S, Iacomi, F, Monini, A, Canneti, A, Passarelli, F & Laghi, V 1996, 'Therapy of chronic hepatitis C with leukocyte interferon-α', Mediterranean Journal of Infectious and Parasitic Diseases, vol. 11, no. 1, pp. 33-39.
Toccaceli, F. ; Russo, V. ; Rosati, S. ; Iacomi, F. ; Monini, A. ; Canneti, A. ; Passarelli, F. ; Laghi, V. / Therapy of chronic hepatitis C with leukocyte interferon-α. In: Mediterranean Journal of Infectious and Parasitic Diseases. 1996 ; Vol. 11, No. 1. pp. 33-39.
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