Terapia dell'angina microvascolare.

Translated title of the contribution: Therapy of microvascular angina

G. A. Lanza, D. Cianflone, A. Buffon, F. Crea, A. Maseri

Research output: Contribution to journalArticle

Abstract

The treatment of microvascular angina (anginal pain resulting from myocardial ischemia due to dysfunction of small coronary arteries) is empiric and often ineffective at present. The poor knowledge of the pathophysiologic mechanisms responsible for the microvascular dysfunction and the possible heterogeneous nature of the disease limit the possibility of a rational therapeutic approach to these patients. The failure of traditional antiischemic therapy is confirmed by the frequent unresponsiveness of angina and by the reduced exercise tolerance with administration of sublingual nitrates. Despite that, beta-blockers and calcium-antagonists, when given either alone or in combination, are beneficial in the control of symptoms in some patients. Alternative forms of treatment, based on some pathophysiological hypotheses and clinical observations, include xanthine derivatives, ACE-inhibitors, alpha-blocking agents, imipramine and, in women, oestrogens. The actual clinical usefulness of these drugs, however, is questionable at present, as their efficacy should be evaluated with more adequate studies in the future.

Original languageItalian
Pages (from-to)169-179
Number of pages11
JournalCardiologia
Volume38
Issue number12 Suppl 1
Publication statusPublished - Dec 1993

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lanza, G. A., Cianflone, D., Buffon, A., Crea, F., & Maseri, A. (1993). Terapia dell'angina microvascolare. Cardiologia, 38(12 Suppl 1), 169-179.