Therapy-resistant cluster headache in childhood: Case report and literature review

F. Antonaci, E. Alfei, F. Piazza, I. De Cillis, U. Balottin

Research output: Contribution to journalArticlepeer-review


The mean age of onset of cluster headache (CH) is in the late third decade. Only few cases of childhood-onset (<14 years) CH have been reported in the literature. We report the case of an 11-year-old boy who suffered from sudden attacks of shock-like, intense pain, localized in the right orbital region, with associated photophobia, phono-phobia, conjunctival injection, lacrimation, nasal congestion, rhinorrhoea and psychomotor agitation. The episodes lasted 60-180 min, and the headache frequency was one to three per day. Physical and neurological examinations, magnetic resonance imaging and blood examinations were normal. The first bout lasted 8 months. Attacks were resistant to every symptomatic and partially to prophylactic treatment that has been tried. The second bout lasted approximately 2 months.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
Issue number2
Publication statusPublished - Feb 2010


  • Childhood
  • Cluster headache
  • Drug resistance

ASJC Scopus subject areas

  • Clinical Neurology


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