Therapy with cyclosporine in psoriatic arthritis

I. Olivieri, C. Salvarani, F. Cantini, L. Macchioni, A. Padula, L. Niccoli, L. Boiardi, I. Portioli

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the efficacy and toxicity of cyclosporin A (CsA) in the treatment of patients with psoriatic arthritis (PsA). Methods: We reviewed the literature dealing with CsA treatment of PsA. Results: In the 1980s, some studies evaluating CsA in severe cases of psoriasis documented an improvement in the associated arthritis. Subsequently, open prospective studies included patients with active peripheral arthritis. Using initial CsA doses of 3 to 6 mg/kg/day, improvement in the clinical parameters was noted. A controlled trial showed that CsA and methotrexate (MTX) are equally effective treatment for PsA. CsA and MTX combination was effective in PsA patients resistant to previous second-line therapy. No studies have evaluated the efficacy of CsA on axial disease and on the progression of radiological damage. The most important side effect was nephrotoxicity. However, of 170 CsA-treated patients in 16 studies, only 10 (6%) discontinued the drug because of renal side effects. Conclusions: CsA seems to be an effective and safe therapy for PsA. However, controlled studies on large number of patients are necessary.

Original languageEnglish
Pages (from-to)36-43
Number of pages8
JournalSeminars in Arthritis and Rheumatism
Volume27
Issue number1
DOIs
Publication statusPublished - 1997

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Keywords

  • Cyclosporine
  • Psoriatic arthritis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Orthopedics and Sports Medicine
  • Rheumatology

Cite this

Olivieri, I., Salvarani, C., Cantini, F., Macchioni, L., Padula, A., Niccoli, L., Boiardi, L., & Portioli, I. (1997). Therapy with cyclosporine in psoriatic arthritis. Seminars in Arthritis and Rheumatism, 27(1), 36-43. https://doi.org/10.1016/S0049-0172(97)80035-2