Levamisole (LMS), an antihelmintic chemical which has been revealed to have an immunomodulating activity, was used by us in 7 pediatric cases: 2 cases of hyper-IgE, 1 case of acute lymphoblastic leukemia with serious respiratory complications, 1 case of chronic granulomatous disease, and 3 cases of chronic muco-cutaneous candidiasis, with involvement of the gastroenteric system in one such case and of the respiratory system in the other two. The therapy was preceded by an immunological study in order to ascertain the true need for immunomodulating treatment. LMS was administered in doses of 2-3 mg/kg day for 3-4 days per week, according to the individual necessity of each patient, for varying lengths of time running from 40 days to 22 months. The best results were obtained in the 2 patients affected by hyper-IgE: the clinical reaction was good in one case and discreet in another, while the various laboratory tests gave better results in both cases and the skin test with DNCB became positive in one. In the case of lymphoblastic leukemia there was a gradual clinical improvement and an increase in the number of E rosettes. In the case of chronic granulomatosis, we obtained a increase in the phagocytosis, an activity which was probably depressed by serious and repeated infections, but the NBT test remained at the same level as had been expected without any noticeable clinical improvement. The results obtained in the 3 cases of chronic mucocutaneous candidiasis were not very encouraging; in fact, there was no clinical improvement. However, it is worth noting that in the only case where the E rosettes were low, there was a marked increase followed by a reduction a month after the treatment was suspended. The only side effect seen was an a-granulocytosis in the case of acute lymphoblastic leukemia, which receded promptly, some days after suspension of treatment: in this case the patient was at high risk due to such a side-effect.
|Translated title of the contribution||Therapy with levamisole in paediatrics. Report of 7 cases|
|Number of pages||11|
|Publication status||Published - 1980|
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