There is no association between coeliac disease and autoimmune pancreatitis

Giulia De Marchi, Giovanna Zanoni, Maria Cristina Conti Bellocchi, Elena Betti, Monica Brentegani, Paola Capelli, Valeria Zuliani, Luca Frulloni, Catherine Klersy, Rachele Ciccocioppo

Research output: Contribution to journalArticle

Abstract

Autoimmune pancreatitis (AIP) is a rare disorder whose association with coeliac disease (CD) has never been investigated, although CD patients display a high prevalence of both endocrine and exocrine pancreatic affections. Therefore, we sought to evaluate the frequency of CD in patients with AIP and in further medical pancreatic disorders. The screening for CD was carried out through the detection of tissue transglutaminase (tTG) autoantibodies in sera of patients retrospectively enrolled and divided in four groups: AIP, chronic pancreatitis, chronic asymptomatic pancreatic hyperenzymemia (CAPH), and control subjects with functional dyspepsia. The search for anti-endomysium autoantibodies was performed in those cases with borderline or positive anti-tTG values. Duodenal biopsy was offered to all cases showing positive results. One patient out of 72 (1.4%) with AIP had already been diagnosed with CD and was following a gluten-free diet, while one case out of 71 (1.4%) with chronic pancreatitis and one out of 92 (1.1%) control subjects were diagnosed with de novo CD. No cases of CD were detected in the CAPH group. By contrast, a high prevalence of cases with ulcerative colitis was found in the AIP group (13.8%). Despite a mutual association between CD and several autoimmune disorders, our data do not support the serologic screening for CD in AIP. Further studies will clarify the usefulness of CD serologic screening in other pancreatic disorders.

Original languageEnglish
Article number1157
JournalNutrients
Volume10
Issue number9
DOIs
Publication statusPublished - Sep 1 2018

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Keywords

  • Autoimmune pancreatitis
  • Coeliac disease
  • Pancreatic disorders
  • Screening

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

De Marchi, G., Zanoni, G., Bellocchi, M. C. C., Betti, E., Brentegani, M., Capelli, P., Zuliani, V., Frulloni, L., Klersy, C., & Ciccocioppo, R. (2018). There is no association between coeliac disease and autoimmune pancreatitis. Nutrients, 10(9), [1157]. https://doi.org/10.3390/nu10091157