Thermal gradient and response to estrogens or antiestrogens in advanced breast cancer

S. Di Pietro, D. Rovini, A. Luini, G. Muscolino, G. Viganotti

Research output: Contribution to journalArticlepeer-review

Abstract

The correlations between the thermal gradient of superficial cancer lesions (before and 15 days after starting treatment) and the end results of hormonal therapies with estrogen and antiestrogens were investigated. 44 women with a median age of over 70 with locally advanced breast cancer and/or metastases mainly located in soft tissues entered the study. 22 patients were treated with diethylstilbestrol sodium diphosphate (20 mg/day i.m.) and the other 22 with tamoxifen (20 mg/day orally). The initial hyperthermia was reduced after 15 days in more than 50% of the cases and remained stationary in the others. The cases with a thermal gradient more than 2°C of the tumors did better, in terms of remission, following therapy (64.7% versus 37.0%). However, an early decrease of the same gradient in the course of therapy appears scantily related to the response. The therapeutic results in the 2 groups were very similar: 45.5% complete or partial regression, with a median duration of more than 8 months, in those treated with diethylstilbestrol and 50%, with a median duration of more than 11 months, in those treated with tamoxifen. Only in some cases of the first group of patients the treatment was discontinued due to severe side effects.

Original languageEnglish
Pages (from-to)459-465
Number of pages7
JournalTumori
Volume66
Issue number4
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Cancer Research

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