Theta-burst stimulation and striatal plasticity in experimental parkinsonism

Veronica Ghiglieri, Valentina Pendolino, Carmelo Sgobio, Vincenza Bagetta, Barbara Picconi, Paolo Calabresi

Research output: Contribution to journalArticlepeer-review

Abstract

Repetitive transcranial magnetic stimulation (rTMS) in humans increases levels of dopamine (DA) in the vicinity of highly active corticostriatal terminals suggesting its use to alleviate symptoms in Parkinson's disease (PD). However, the effects of rTMS on corticostriatal plasticity have not been explored. Here we show that a single-session of cortical rTMS using intermittent theta-burst stimulation (iTBS) pattern increases striatal excitability and rescues corticostriatal long-term depression (LTD) in a significant number of field excitatory postsynaptic potentials (fEPSP) recorded from hemiparkinsonian rats. These data indicate that cortical iTBS affects neuronal activity of subcortical regions, providing experimental evidence for its use in clinical settings.

Original languageEnglish
Pages (from-to)395-398
Number of pages4
JournalExperimental Neurology
Volume236
Issue number2
DOIs
Publication statusPublished - Aug 2012

Keywords

  • Corticostriatal pathway
  • Neuromodulation
  • Parkinson's disease
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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