Theta-burst stimulation and striatal plasticity in experimental parkinsonism

Veronica Ghiglieri; Valentina Pendolino; Carmelo Sgobio; Vincenza Bagetta; Barbara Picconi; Paolo Calabresi

doi:10.1016/j.expneurol.2012.04.020

Theta-burst stimulation and striatal plasticity in experimental parkinsonism

Veronica Ghiglieri, Valentina Pendolino, Carmelo Sgobio, Vincenza Bagetta, Barbara Picconi, Paolo Calabresi

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Repetitive transcranial magnetic stimulation (rTMS) in humans increases levels of dopamine (DA) in the vicinity of highly active corticostriatal terminals suggesting its use to alleviate symptoms in Parkinson's disease (PD). However, the effects of rTMS on corticostriatal plasticity have not been explored. Here we show that a single-session of cortical rTMS using intermittent theta-burst stimulation (iTBS) pattern increases striatal excitability and rescues corticostriatal long-term depression (LTD) in a significant number of field excitatory postsynaptic potentials (fEPSP) recorded from hemiparkinsonian rats. These data indicate that cortical iTBS affects neuronal activity of subcortical regions, providing experimental evidence for its use in clinical settings.

Original language	English
Pages (from-to)	395-398
Number of pages	4
Journal	Experimental Neurology
Volume	236
Issue number	2
DOIs	https://doi.org/10.1016/j.expneurol.2012.04.020
Publication status	Published - Aug 2012

Keywords

Corticostriatal pathway
Neuromodulation
Parkinson's disease
Synaptic plasticity

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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10.1016/j.expneurol.2012.04.020

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abstract = "Repetitive transcranial magnetic stimulation (rTMS) in humans increases levels of dopamine (DA) in the vicinity of highly active corticostriatal terminals suggesting its use to alleviate symptoms in Parkinson's disease (PD). However, the effects of rTMS on corticostriatal plasticity have not been explored. Here we show that a single-session of cortical rTMS using intermittent theta-burst stimulation (iTBS) pattern increases striatal excitability and rescues corticostriatal long-term depression (LTD) in a significant number of field excitatory postsynaptic potentials (fEPSP) recorded from hemiparkinsonian rats. These data indicate that cortical iTBS affects neuronal activity of subcortical regions, providing experimental evidence for its use in clinical settings.",

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AU - Ghiglieri, Veronica

AU - Pendolino, Valentina

AU - Sgobio, Carmelo

AU - Bagetta, Vincenza

AU - Picconi, Barbara

AU - Calabresi, Paolo

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KW - Synaptic plasticity

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Theta-burst stimulation and striatal plasticity in experimental parkinsonism

Abstract

Keywords

ASJC Scopus subject areas

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