TY - JOUR
T1 - Theta-burst stimulation and striatal plasticity in experimental parkinsonism
AU - Ghiglieri, Veronica
AU - Pendolino, Valentina
AU - Sgobio, Carmelo
AU - Bagetta, Vincenza
AU - Picconi, Barbara
AU - Calabresi, Paolo
PY - 2012/8
Y1 - 2012/8
N2 - Repetitive transcranial magnetic stimulation (rTMS) in humans increases levels of dopamine (DA) in the vicinity of highly active corticostriatal terminals suggesting its use to alleviate symptoms in Parkinson's disease (PD). However, the effects of rTMS on corticostriatal plasticity have not been explored. Here we show that a single-session of cortical rTMS using intermittent theta-burst stimulation (iTBS) pattern increases striatal excitability and rescues corticostriatal long-term depression (LTD) in a significant number of field excitatory postsynaptic potentials (fEPSP) recorded from hemiparkinsonian rats. These data indicate that cortical iTBS affects neuronal activity of subcortical regions, providing experimental evidence for its use in clinical settings.
AB - Repetitive transcranial magnetic stimulation (rTMS) in humans increases levels of dopamine (DA) in the vicinity of highly active corticostriatal terminals suggesting its use to alleviate symptoms in Parkinson's disease (PD). However, the effects of rTMS on corticostriatal plasticity have not been explored. Here we show that a single-session of cortical rTMS using intermittent theta-burst stimulation (iTBS) pattern increases striatal excitability and rescues corticostriatal long-term depression (LTD) in a significant number of field excitatory postsynaptic potentials (fEPSP) recorded from hemiparkinsonian rats. These data indicate that cortical iTBS affects neuronal activity of subcortical regions, providing experimental evidence for its use in clinical settings.
KW - Corticostriatal pathway
KW - Neuromodulation
KW - Parkinson's disease
KW - Synaptic plasticity
UR - http://www.scopus.com/inward/record.url?scp=84863430601&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863430601&partnerID=8YFLogxK
U2 - 10.1016/j.expneurol.2012.04.020
DO - 10.1016/j.expneurol.2012.04.020
M3 - Article
C2 - 22569102
AN - SCOPUS:84863430601
VL - 236
SP - 395
EP - 398
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 2
ER -