Thiazide diuretics in renal hypercalciuria.

A. Aroldi; G. Graziani; G. Mioni; M. Cecchettin; D. Brancaccio; C. Galmozzi; M. Surian; A. Cantaluppi; C. Ponticelli

Thiazide diuretics in renal hypercalciuria.

A. Aroldi, G. Graziani, G. Mioni, M. Cecchettin, D. Brancaccio, C. Galmozzi, M. Surian, A. Cantaluppi, C. Ponticelli

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Forty-six renal hypercalciuric normocalcaemic patients were treated with hydrochlorothiazide (50mg/day) and amiloride (5 mg/day), both to reduce new stone formation and to suppress parathyroid hyperfunction. A reduction of hypercalciuria and suppression of parathyroid hyperactivity were observed in 41 patients, while in the other five patients no evidence of parathyroid suppression was found and hypercalcaemia developed. Four of five patients underwent parathyroidectomy which was followed by a normalisation of biochemical signs of hyperparathyroidism. These results suggest that the appearance of hypercalcaemia in renal hypercalciuric patients during hydrochlorothiazide/amiloride treatment may be of diagnostic value in unmasking pharmacologically non-suppressible normocalcaemic hyperparathyroidism.

Original language	English
Pages (from-to)	571-576
Number of pages	6
Journal	Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
Volume	16
Publication status	Published - 1979

ASJC Scopus subject areas

Medicine(all)

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Thiazide diuretics in renal hypercalciuria. / Aroldi, A.; Graziani, G.; Mioni, G.; Cecchettin, M.; Brancaccio, D.; Galmozzi, C.; Surian, M.; Cantaluppi, A.; Ponticelli, C.

In: Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, Vol. 16, 1979, p. 571-576.

Research output: Contribution to journal › Article › peer-review

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AU - Aroldi, A.

AU - Graziani, G.

AU - Mioni, G.

AU - Cecchettin, M.

AU - Brancaccio, D.

AU - Galmozzi, C.

AU - Surian, M.

AU - Cantaluppi, A.

AU - Ponticelli, C.

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AB - Forty-six renal hypercalciuric normocalcaemic patients were treated with hydrochlorothiazide (50mg/day) and amiloride (5 mg/day), both to reduce new stone formation and to suppress parathyroid hyperfunction. A reduction of hypercalciuria and suppression of parathyroid hyperactivity were observed in 41 patients, while in the other five patients no evidence of parathyroid suppression was found and hypercalcaemia developed. Four of five patients underwent parathyroidectomy which was followed by a normalisation of biochemical signs of hyperparathyroidism. These results suggest that the appearance of hypercalcaemia in renal hypercalciuric patients during hydrochlorothiazide/amiloride treatment may be of diagnostic value in unmasking pharmacologically non-suppressible normocalcaemic hyperparathyroidism.

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Thiazide diuretics in renal hypercalciuria.

Abstract

ASJC Scopus subject areas

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