TY - JOUR
T1 - Thiazolidinedione effects on blood pressure in diabetic patients with metabolic syndrome treated with glimepiride
AU - Derosa, Giuseppe
AU - Cicero, Arrigo Francesco Giuseppe
AU - D'Angelo, Angela
AU - Gaddi, Antonio
AU - Ragonesi, Pietro Dario
AU - Piccinni, Mario Nello
AU - Salvadeo, Sibilla
AU - Ciccarelli, Leonardina
AU - Pricolo, Fabio
AU - Ghelfi, Morena
AU - Ferrari, Ilaria
AU - Montagna, Lorenza
AU - Fogari, Roberto
PY - 2005/11
Y1 - 2005/11
N2 - The aim of our study was to compare the long-term effect of pioglitazone and rosiglitazone on blood pressure control of diabetic patients with metabolic syndrome treated with glimepiride. We evaluated 91 type 2 diabetic patients with metabolic syndrome. All were required to have been diagnosed as diabetic for at least 6 months, and to have failed to achieve glycemic control by dietary changes and the maximum tolerated dose of the oral hypoglycemic agents sulfonylureas or metformin. All patients took a fixed dose of 4 mg/day glimepiride. We administered pioglitazone (15 mg/day) or rosiglitazone (4 mg/day) for 12 months in a randomized, double-blind fashion, and evaluated body mass index (BMI), glycemic control, blood pressure and heart rate (HR) throughout the treatment period. A total of 87 patients completed the study and were randomized to receive double-blind treatment with pioglitazone or rosiglitazone. An increase in BMI was observed after 12 months (p1c), mean fasting plasma glucose (FPG), postprandial plasma glucose (PPG), fasting plasma insulin (FPI), and postprandial plasma insulin (PPI) in both treatment groups (p
AB - The aim of our study was to compare the long-term effect of pioglitazone and rosiglitazone on blood pressure control of diabetic patients with metabolic syndrome treated with glimepiride. We evaluated 91 type 2 diabetic patients with metabolic syndrome. All were required to have been diagnosed as diabetic for at least 6 months, and to have failed to achieve glycemic control by dietary changes and the maximum tolerated dose of the oral hypoglycemic agents sulfonylureas or metformin. All patients took a fixed dose of 4 mg/day glimepiride. We administered pioglitazone (15 mg/day) or rosiglitazone (4 mg/day) for 12 months in a randomized, double-blind fashion, and evaluated body mass index (BMI), glycemic control, blood pressure and heart rate (HR) throughout the treatment period. A total of 87 patients completed the study and were randomized to receive double-blind treatment with pioglitazone or rosiglitazone. An increase in BMI was observed after 12 months (p1c), mean fasting plasma glucose (FPG), postprandial plasma glucose (PPG), fasting plasma insulin (FPI), and postprandial plasma insulin (PPI) in both treatment groups (p
KW - Glimepiride
KW - Metabolic syndrome
KW - Pioglitazone
KW - Rosiglitazone
KW - Thiazolidinediones
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U2 - 10.1291/hypres.28.917
DO - 10.1291/hypres.28.917
M3 - Article
C2 - 16555581
AN - SCOPUS:31744442785
VL - 28
SP - 917
EP - 924
JO - Hypertension Research
JF - Hypertension Research
SN - 0916-9636
IS - 11
ER -