Thiazolidinedione effects on blood pressure in diabetic patients with metabolic syndrome treated with glimepiride

Giuseppe Derosa, Arrigo Francesco Giuseppe Cicero, Angela D'Angelo, Antonio Gaddi, Pietro Dario Ragonesi, Mario Nello Piccinni, Sibilla Salvadeo, Leonardina Ciccarelli, Fabio Pricolo, Morena Ghelfi, Ilaria Ferrari, Lorenza Montagna, Roberto Fogari

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The aim of our study was to compare the long-term effect of pioglitazone and rosiglitazone on blood pressure control of diabetic patients with metabolic syndrome treated with glimepiride. We evaluated 91 type 2 diabetic patients with metabolic syndrome. All were required to have been diagnosed as diabetic for at least 6 months, and to have failed to achieve glycemic control by dietary changes and the maximum tolerated dose of the oral hypoglycemic agents sulfonylureas or metformin. All patients took a fixed dose of 4 mg/day glimepiride. We administered pioglitazone (15 mg/day) or rosiglitazone (4 mg/day) for 12 months in a randomized, double-blind fashion, and evaluated body mass index (BMI), glycemic control, blood pressure and heart rate (HR) throughout the treatment period. A total of 87 patients completed the study and were randomized to receive double-blind treatment with pioglitazone or rosiglitazone. An increase in BMI was observed after 12 months (p1c), mean fasting plasma glucose (FPG), postprandial plasma glucose (PPG), fasting plasma insulin (FPI), and postprandial plasma insulin (PPI) in both treatment groups (p

Original languageEnglish
Pages (from-to)917-924
Number of pages8
JournalHypertension Research
Issue number11
Publication statusPublished - Nov 2005


  • Glimepiride
  • Metabolic syndrome
  • Pioglitazone
  • Rosiglitazone
  • Thiazolidinediones

ASJC Scopus subject areas

  • Internal Medicine


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