Thin melanoma and late recurrences: It is never too thin and never too late

Antonio Giovanni Richetta, Ugo Bottoni, Giovanni Paolino, Rita Clerico, Carmen Cantisani, Marina Ambrifi, Paola Corsetti, Stefano Calvieri

Research output: Contribution to journalArticlepeer-review


In the absence of risk factors, thin melanomas (TM) present a long-term survival; however, recurrences may occur. We describe the predictive clinicopathological features of patients with metastatic TM. Kaplan-Meier product was performed for the survival analysis, while Cox proportional hazards regression was used to evaluate the effect of the clinicopathological features on disease-free survival (DFS) and overall survival (OS). Median DFS of the entire cohort was 26 months and three patients developed late metastases. Nine patients developed extra-nodal metastases as first recurrence, while cases of positive sentinel lymph node biopsy (SLNB) were not found. DFS and OS varied according to the clinicopathological features, but only ulceration remained the main statistical significance value. According to our results, a hypothetical use of SLNB in TM without other risk factors is not currently feasible. No consensus exists as to which patients with TM are at risk for metastases or late recurrences.

Original languageEnglish
Article number909
JournalMedical Oncology
Issue number4
Publication statusPublished - 2014


  • Late recurrences
  • Metastatses
  • Sentinel lymph node biopsy
  • Survival
  • Thin melanoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Hematology
  • Medicine(all)


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