Thioalkyl derivatives of vitamin K3 and vitamin K3 oxide inhibit growth of Hep3B and HepG2 cells

Jeffrey Kerns, Sriram Naganathan, Paul Dowd, Frances M. Finn, Brian Carr

Research output: Contribution to journalArticle

Abstract

A new hypothesis regarding the effect of vitamin K3 on hepatoma cell growth is presented. In brief, exploration of cell growth activity has been identified with the action of p34(cdc2) kinase and its associated protein tyrosine phosphatase. After exploring a series of substituted derivatives of vitamin K and vitamin K3 oxide, we suggest a mechanism involving alkylation at the active-site cysteine for the inhibition of the protein tyrosine phosphatase which controls the activity of the p34(cdc2) kinase.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalBioorganic Chemistry
Volume23
Issue number2
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery

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